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Comparative Study
. 2017 Apr;58(4):196-200.
doi: 10.11622/smedj.2016113. Epub 2016 Jun 29.

Prognostic factors for candidaemia in intensive care unit patients: a retrospective analysis

Yasumasa Kawano  1 , Atsushi Togawa  2 , Yoshihiko Nakamura  1 , Mariko Mizunuma  1 , Reiko Yamasaki  1 , Kota Hoshino  1 , Takeshi Nishida  1 , Hiroyasu Ishikura  1
Affiliations
Comparative Study

Prognostic factors for candidaemia in intensive care unit patients: a retrospective analysis

Yasumasa Kawano et al. Singapore Med J. 2017 Apr.

Abstract

Introduction: Candidaemia, recognised as a fairly common disease among intensive care unit (ICU) patients, carries a poor prognosis. However, as studies on the prognostic factors associated with candidaemia in ICU patients are limited, this study aimed to establish the best prognostic factor for ICU patients with candidaemia in a tertiary care hospital in Japan.

Methods: We conducted a retrospective cohort study of patients with candidaemia in the emergency ICU at Fukuoka University Hospital, Fukuoka, Japan, from April 2010 to March 2015. Demographic and clinical data was collected from the patients' medical records and laboratory databases.

Results: A total of 25 patients were included in the study. However, 18 patients died during hospitalisation, resulting in an in-hospital mortality rate of 72.0%. The variables of Sequential Organ Failure Assessment (SOFA) score and cumulative number of risk factors for invasive candidiasis showed significant differences between patients in the survivor and non-survivor groups (p < 0.05). The areas under the receiver operating characteristic curves for the SOFA score and cumulative number of risk factors for invasive candidiasis were 0.873 (95% confidence interval [CI] 0.72-1.00) and 0.937 (95% CI 0.84-1.00), respectively.

Conclusion: Our results suggest that the cumulative number of risk factors for invasive candidiasis was the most useful prognostic indicator for candidaemia in ICU patients.

Keywords: candidaemia; intensive care unit; prognostic factor.

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Figures

Box 1
Box 1
Risk factors for invasive candidiasis.(3)
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