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Case Reports
. 2016 Jun 27;8(6):461-6.
doi: 10.4240/wjgs.v8.i6.461.

Solitary fibrous tumor of the pancreas: Case report and review of the literature

Daniel Paramythiotis  1 , Konstantinia Kofina  1 , Petros Bangeas  1 , Fani Tsiompanou  1 , Georgia Karayannopoulou  1 , George Basdanis  1
Affiliations
Case Reports

Solitary fibrous tumor of the pancreas: Case report and review of the literature

Daniel Paramythiotis et al. World J Gastrointest Surg. .

Abstract

Solitary fibrous tumor (SFT) is a mesenchymal tumor typically located in the pleura, but can also be found as an asymptomatic mass in other areas, including the liver, peritoneum, kidney and salivary glands. However, SFT rarely locates in the pancreas. We present such a case of pancreatic SFT, along with a review of all reported cases. A 55-year-old man was treated surgically for an asymptomatic pancreatic mass after a rigorous preoperative control. Histologic examination of the resected specimen showed characteristics of an SFT. As only 15 cases of pancreatic SFT have been reported so far, an attempt to compare the cases was considered intriguing. We found that patients with pancreatic SFT were mainly women (81.25%), with a median age of 54 years at the time of diagnosis and a median tumor size of 5.83 cm. Pancreatic SFTs were revealed incidentally in 50% of cases, and all of them showed an enhancement through arterial computed tomography. All tumors were positive for CD34, ten were positive for Bcl-2, and twelve were negative for S100. The diagnosis of this pancreatic tumor is established by a combination of clinical suspicion, imaging procedures and histological findings, and is confirmed by immunohistochemical staining. Although the behavior of SFTs is rather benign, close clinical follow-up is recommended due to a potentially malignant nature.

Keywords: Differential diagnosis; Mesenchymal tumors; Pancreas; Solitary fibrous tumor; Solitary fibrous tumor treatment.

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Figures

Figure 1
Figure 1
Ultrasound echo showing a 2.8 cm × 3.1 cm hypoechoic solid mass located on the pancreatic body.
Figure 2
Figure 2
Computed tomography scan revealing a 3.9 cm exophytic mass, arising from the pancreatic body, which was enhanced from the arterial to portal venous phase.
Figure 3
Figure 3
Intra-operative appearance of the pancreatic mass.
Figure 4
Figure 4
Pancreatic mass specimen.
Figure 5
Figure 5
Solitary fibrous tumor with a hyalinized area, HE stain. Magnification: × 400 .
Figure 6
Figure 6
Immunohistochemical staining (brown) for CD34 (A), CD99 (B) and Bcl-2 (C). Magnification: × 400.
See this image and copyright information in PMC

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