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Comment
. 2016 Oct-Dec;33(4):150-154.
doi: 10.1016/j.hipert.2016.05.003. Epub 2016 Jun 28.

[Benefits of spironolactone as the optimal treatment for drug resistant hypertension. Pathway-2 trial review]

[Article in Spanish]
J C Prado  1 , L M Ruilope  2 , J Segura  3
Affiliations
Comment

[Benefits of spironolactone as the optimal treatment for drug resistant hypertension. Pathway-2 trial review]

[Article in Spanish]
J C Prado et al. Hipertens Riesgo Vasc. 2016 Oct-Dec.

Abstract

Pathway-2 is the first randomised, double-blind and crossover trial that compares spironolactone as a fourth drug with alfa-blocker, beta-blocker and placebo. This study shows that spironolactone is the drug with more possibilities of success for the management of patients with difficult-to-treat hypertension in patients with a combination of three drugs and poor control. The results validate the widespread treatment with mineralocorticoid receptor antagonists in resistant hypertension.

Keywords: Antagonistas del receptor de mineralocorticoides; Denervación renal; Espironolactona; Hipertensión arterial resistente; Mineralocorticoid receptor antagonists; Renal denervation; Resistant hypertension; Spironolactone.

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