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Observational Study
. 2016 Dec 1;67(12):1300-1306.
doi: 10.1176/appi.ps.201500438. Epub 2016 Jul 1.

The RAISE Connection Program: Psychopharmacological Treatment of People With a First Episode of Schizophrenia

Julie A Kreyenbuhl  1 , Deborah R Medoff  1 , Joseph P McEvoy  1 , Thomas E Smith  1 , Ann L Hackman  1 , Ilana R Nossel  1 , Lisa B Dixon  1 , Susan M Essock  1 , Robert W Buchanan  1
Affiliations
Observational Study

The RAISE Connection Program: Psychopharmacological Treatment of People With a First Episode of Schizophrenia

Julie A Kreyenbuhl et al. Psychiatr Serv. .

Abstract

Objective: This study examined the adherence of psychiatrists to the Schedule of Recommended First and Second Line Antipsychotic Medications ("Antipsychotic Schedule"), which was implemented in two Recovery After an Initial Schizophrenia Episode (RAISE) Connection Program Implementation and Evaluation Study clinics.

Methods: Sixty-five individuals with a first episode of psychosis were enrolled in the RAISE Connection Program clinics. Two psychiatrists received training and ongoing consultation on use of a shared decision-making approach to prescribing antipsychotic medications according to the Antipsychotic Schedule. Information about participants, prescribed antipsychotic medications, and completion of side-effect assessments were obtained from standardized research assessments and chart extractions. Descriptive statistics were used to characterize the extent to which patterns of antipsychotic prescribing and side-effect monitoring were consistent with the Antipsychotic Schedule.

Results: Ninety-two percent of participants were prescribed an antipsychotic medication and received the medication on 76%±35% of the days they were in treatment. Seventy-seven percent of participants were prescribed at least one Antipsychotic Schedule first-line antipsychotic, 20% were prescribed olanzapine, and 10% received a trial of clozapine. Regarding monitoring for metabolic side effects, 92% of participants had at least one weight recorded, 72% had at least one blood glucose measure recorded, and 62% had at least one lipid profile recorded.

Conclusions: In the context of a study in which training and ongoing clinical supervision by experts was provided to psychiatrists and shared decision making was encouraged, antipsychotic prescribing patterns closely adhered to recommendations established by the RAISE Connection Program.

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Conflict of interest statement

Disclosures

Dr. A, Dr. B, Dr. D, Dr. E, Dr. F, and Dr. H, report no potential conflicts of interest.

Figures

Figure 1
Figure 1
Percentage of RAISE CP participants prescribed antipsychotic treatment
Figure 1
Figure 1
Percentage of RAISE CP participants prescribed antipsychotic treatment
See this image and copyright information in PMC

References

    1. Buchanan RW, Kreyenbuhl J, Kelly DL, et al. The 2009 Schizophrenia PORT Psychopharmacological Treatment Recommendations and Summary Statements. Schizophrenia Bulletin. 2010;36:71–93. - PMC - PubMed
    1. Lieberman JA, Phillips M, Gu H, et al. Atypical and conventional antipsychotic drugs in treatment naïve first episode schizophrenia: a 52-week randomized trial of clozapine vs. chlorpromazine. Neuropsychopharmacology. 2003;28:995–1003. - PubMed
    1. Schooler N, Rabinowitz J, Davidson M, et al. Risperidone and haloperidol in first-episode psychosis: A long-term randomized trial. American Journal of Psychiatry. 2005;162:947–953. - PubMed
    1. Robinson DG, Woerner MG, Napolitano B, et al. Randomized comparison of olanzapine versus risperidone for the treatment of first-episode schizophrenia: 4-month outcomes. American Journal of Psychiatry. 2006;163:2096–2102. - PubMed
    1. Gaebel W, Riesbeck M, Wolwer W, et al. Maintenance treatment with risperidone or low-dose haloperidol in first-episode schizophrenia: 1 year results of a randomized controlled trial within the German Research Network on Schizophrenia. Journal of Clinical Psychiatry. 2007;68:1763–1774. - PubMed

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