Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2016 Jul;29(3):313-4.
doi: 10.1080/08998280.2016.11929449.

Lactate levels with glioblastoma multiforme

Arunpreet Singh Kahlon  1 , Mariam Alexander  1 , Arundeep Kahlon  1 , Jonathan Wright  1
Affiliations
Case Reports

Lactate levels with glioblastoma multiforme

Arunpreet Singh Kahlon et al. Proc (Bayl Univ Med Cent). 2016 Jul.

Abstract

A 37-year-old woman with known glioblastoma multiforme was admitted for treatment of new deep vein thrombosis. Anion gap and plasma lactate levels were found to be elevated. Magnetic resonance imaging of the brain showed a stable, advanced glioblastoma multiforme. All causes of lactic acidosis, including infections and medications, were ruled out. Aggressive tumors have been shown to produce lactate levels in minute quantities in their microenvironment, which helps them metastasize and evade immune response and even radiation.

PubMed Disclaimer

Figures

Figure.
Figure.
MRI of the brain showing glioblastoma multiforme in the right brain stem.
See this image and copyright information in PMC

References

    1. Brizel DM. Schroeder T. Scher RL. Walenta S. Clough RW. Dewhirst MW. Mueller-Klieser W. Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001;51(2):349–353. - PubMed
    1. Andersen LW. Mackenhauer J. Roberts JC. Berg KM. Cocchi MN. Donnino MW. Etiology and therapeutic approach to elevated lactate levels. Mayo Clin Proc. 2013;88(10):1127–1140. - PMC - PubMed
    1. Warburg O. Wind F. Negelein E. The metabolism of tumors in the body. J Gen Physiol. 1927;8(6):519–530. - PMC - PubMed
    1. Brooks GA. Lactate production under fully aerobic conditions: the lactate shuttle during rest and exercise. Fed Proc. 1986;45(13):2924–2929. - PubMed
    1. Vander Heiden MG. Cantley LC. Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324(5930):1029–1033. - PMC - PubMed

Publication types

LinkOut - more resources