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. 2016 Jul-Dec;8(2):77-84.
doi: 10.4103/0974-2727.180786.

Advanced Atherogenic Index for the Assessment of Consolidated Lipid Risk in Premature Coronary Artery Disease Patients in India

Sanjiv Kumar Bansal  1 , Sarita Agarwal  2 , Mridul Kumar Daga  3
Affiliations

Advanced Atherogenic Index for the Assessment of Consolidated Lipid Risk in Premature Coronary Artery Disease Patients in India

Sanjiv Kumar Bansal et al. J Lab Physicians. 2016 Jul-Dec.

Abstract

Introduction: The high prevalence, severity, and prematurity of coronary artery disease (CAD) in the Indian population cannot be completely explained by the conventional lipid parameters and the existing lipid indices.

Aims and objectives: To calculate newly defined advanced atherogenic index (AAI) in premature CAD patients and compare it between cases and controls and Correlate its values with the existing indices.

Material and methods: One hundred and twenty premature CAD patients and an equal number of age and sex matched healthy individuals were included in this study. Lipid profile and nonconventional lipid parameters like oxidized Low density lipoprotein (OX LDL), small dense LDL (SD LDL), lipoprotein (a) apolipoprotein B (Apo B), and apolipoprotein A1 (Apo A1) were estimated and their values were used to define AAI and existing lipid indices like AI, lipid tetrad index (LTI) and lipid pentad index (LPI).

Results: The mean age of cases and controls was 37.29 + 4.50 and 36.13 + 3.53 years, respectively. The value of AAI was highly significant in cases (3461.22 ± 45.20) as compared to controls (305.84 ± 21.80). AAI has shown better statistical significance and correlation (P < 0.0001, r = 0.737) as compared to the earlier indices such as AI (P < 0.01, r = 0.52), LTI (P < 0.001, r = 0.677) and LPI (P < 0.001, r = 0.622) in premature CAD. Kolmogorov D statistic and cumulative distribution function plot has shown that AAI can discriminate cases and controls more accurately as compared to the earlier indices.

Conclusion: Statistically AAI appears to be a better marker of consolidated lipid risk in premature CAD patients as compared to the earlier indices.

Keywords: Advanced atherogenic index; lipid pentad index; lipid tetrad index; premature coronary artery disease.

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Figures

Figure 1
Figure 1
Age distribution in cases and controls
Figure 2
Figure 2
Gender distribution in cases
Figure 3
Figure 3
Cumulative distribution function plots of atherogenic index in cases and controls (staircase curves show empirical cumulative distribution function from the observed data and smooth curves are lognormal cumulative distribution function fit of the observed data)
Figure 4
Figure 4
Cumulative distribution function plots of lipid tetrad index in cases and controls (staircase curves show empirical cumulative distribution function from the observed data and smooth curves are lognormal cumulative distribution function fit of the observed data)
Figure 5
Figure 5
Cumulative distribution function plots of lipid pentad index in cases and controls (staircase curves show empirical cumulative distribution function from the observed data and Smooth curves are lognormal cumulative distribution function fit of the observed data)
Figure 6
Figure 6
Cumulative distribution function plots of advanced atherogenic index in cases and controls (staircase curves show empirical cumulative distribution function from the observed data and smooth curves are lognormal cumulative distribution function fit of the observed data)
Figure 7
Figure 7
Histogram of advanced atherogenic index with lognormal fitcurve in controls
Figure 8
Figure 8
Histogram of advanced atherogenic index with lognormal fit curve in cases
Figure 9
Figure 9
Histogram of advanced atherogenic index in cases and controls
See this image and copyright information in PMC

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