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. 2016 Jun 13:9:3485-92.
doi: 10.2147/OTT.S99942. eCollection 2016.

PTEN gene mutations correlate to poor prognosis in glioma patients: a meta-analysis

Feng Han  1 , Rong Hu  2 , Hua Yang  1 , Jian Liu  1 , Jianmei Sui  1 , Xin Xiang  1 , Fan Wang  1 , Liangzhao Chu  1 , Shibin Song  1
Affiliations

PTEN gene mutations correlate to poor prognosis in glioma patients: a meta-analysis

Feng Han et al. Onco Targets Ther. .

Abstract

Background: We conducted this meta-analysis based on eligible trials to investigate the relationship between phosphatase and tensin homolog (PTEN) genetic mutation and glioma patients' survival.

Methods: PubMed, Web of Science, and EMBASE were searched for eligible studies regarding the relationship between PTEN genetic mutation and glioma patients' survival. The primary outcome was the overall survival of glioma patient with or without PTEN genetic mutation, and second outcome was prognostic factors for the survival of glioma patient. A fixed-effects or random-effects model was used to pool the estimates according to the heterogeneity among the included studies.

Results: Nine cohort studies, involving 1,173 patients, were included in this meta-analysis. Pooled results suggested that glioma patients with PTEN genetic mutation had a significant shorter overall survival than those without PTEN genetic mutation (hazard ratio [HR] =2.23, 95% confidence interval [CI]: 1.35, 3.67; P=0.002). Furthermore, subgroup analysis indicated that this association was only observed in American patients (HR =2.19, 95% CI: 1.23, 3.89; P=0.008), but not in Chinese patients (HR =1.44, 95% CI: 0.29, 7.26; P=0.657). Histopathological grade (HR =1.42, 95% CI: 0.07, 28.41; P=0.818), age (HR =0.94, 95% CI: 0.43, 2.04; P=0.877), and sex (HR =1.28, 95% CI: 0.55, 2.98; P=0.564) were not significant prognostic factors for the survival of patients with glioma.

Conclusion: Current evidence indicates that PTEN genetic mutation is associated with poor prognosis in glioma patients. However, this finding is derived from data in observational studies, potentially subject to selection bias, and hence well conducted, high-quality randomized controlled trials are warranted.

Keywords: PTEN genetic mutation; glioma; meta-analysis.

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Figures

Figure 1
Figure 1
Search strategy and flowchart for the meta-analysis.
Figure 2
Figure 2
Forest plot showing the relationship between PTEN mutations and prognosis in patients with glioma. Note: Weights are from random-effects analysis. Abbreviations: CI, confidence interval; HR, hazard ratio; PTEN, phosphatase and tensin homolog.
Figure 3
Figure 3
Forest plot showing the prognostic factors for the overall survival of glioma patients. Note: Weights are from random-effects analysis. Abbreviations: CI, confidence interval; HR, hazard ratio.
See this image and copyright information in PMC

References

    1. Wrensch M, Minn Y, Chew T, Bondy M, Berger MS. Epidemiology of primary brain tumors: current concepts and review of the literature. Neuro Oncol. 2002;4(4):278–299. - PMC - PubMed
    1. Central brain tumor registry of the United States. Available from: http://www.CBTRUS.org.
    1. Ohgaki H, Dessen P, Jourde B, et al. Genetic pathways to glioblastoma: a population-based study. Cancer Res. 2004;64(19):6892–6899. - PubMed
    1. See SJ, Gilbert MR. Anaplastic astrocytoma: diagnosis, prognosis, and management. Semin Oncol. 2004;31(5):618–634. - PubMed
    1. Butowski NA, Sneed PK, Chang SM. Diagnosis and treatment of recurrent high-grade astrocytoma. J Clin Oncol. 2006;24(8):1273–1280. - PubMed