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. 2013 Dec;41(6):200-5.
doi: 10.5152/TJAR.2013.33. Epub 2013 May 23.

The Effect of Different End-tidal Desflurane Concentrations on Bispectral Index Values in Normal Children and Children with Cerebral Palsy

Aysun Ankay Yılbaş  1 , Banu Ayhan  2 , Seda Banu Akıncı  2 , Fatma Sarıcaoğlu  2 , Ülkü Aypar  2
Affiliations

The Effect of Different End-tidal Desflurane Concentrations on Bispectral Index Values in Normal Children and Children with Cerebral Palsy

Aysun Ankay Yılbaş et al. Turk J Anaesthesiol Reanim. 2013 Dec.

Abstract

Objective: In this study, we aimed to compare the effects of different intraoperative end-tidal desflurane concentrations on bispectral index (BIS) values in normal children and children with cerebral palsy.

Methods: Twenty normal children (Group N) and 20 children with non-communicative/nonverbal cerebral palsy (Group CP), between 2 and 15 years of age, undergoing elective orthopaedic surgery were included in the study. Following premedication with midazolam, anaesthesia was induced by infusing 1% propofol at a rate of 200 mL hr(-1) until BIS reached 50. Heart rate, blood pressure and BIS values were recorded before and after the induction of anaesthesia, at steady-state end-tidal concentrations of 4% and 6% desflurane, and after emergence from anaesthesia. A p value <0.05 was considered significant in the statistical analyses, including Kolmogorov-Smirnov, t-test, paired samples t-test and chi-square test.

Results: The time to extubation and eye opening after discontinuation of anaesthesia was longer in Group CP. BIS values before the induction of anaesthesia, at a steady-state end-tidal desflurane concentration of 4% and after emergence from the anaesthetic were significantly lower in Group CP. At a steady-state end-tidal desflurane concentration of 6%, BIS values were slightly lower in Group CP but this difference was not statistically significant.

Conclusion: Based on the data obtained, we concluded that BIS monitoring in children with cerebral palsy can be useful in terms of decreasing adverse effects and drug interactions due to multiple drug usage by reducing the use of anaesthetic agents and improving emergence from the anaesthetic.

Keywords: Cerebral palsy; bispectral index; desflurane; paediatric anaesthesia.

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Figures

Figure 1
Figure 1
Comparison of heart rate and mean arterial pressures (mmHg) at T3 and T4 stages.
Figure 2
Figure 2
Comparison of the mean BIS values at T3 and T4 stages.
See this image and copyright information in PMC

References

    1. Nolan J, Chalkiadis GA, Low J, Olesch CA, Brown TC. Anaesthesia and pain management in cerebral palsy. Anaesthesia. 2000;55:32–41. http://dx.doi.org/10.1046/j.1365-2044.2000.01065.x. - DOI - PubMed
    1. Nelson KB, Emery ES., 3rd Birth asphyxia and the neonatal brain: what do we know and when do we know it? Clin Perinatol. 1993;20:327–44. - PubMed
    1. Dolk H, Parkes J, Hill N. Trends in the prevalence of cerebral palsy in Northern Ireland, 1981–1997. Dev Med Child Neurol. 2006;48:406–12. http://dx.doi.org/10.1111/j.1469-8749.2006.tb01287.x. - DOI - PubMed
    1. Theroux MC, Akins RE. Surgery and anesthesia for children who have cerebral palsy. Anesthesiol Clin North America. 2005;23:733–43. http://dx.doi.org/10.1016/j.atc.2005.08.001. - DOI - PubMed
    1. Denman WT, Swanson EL, Rosow D, Ezbicki K, Connors PD, Rosow CE. Pediatric evaluation of the bispectral index (BIS) monitor and correlation of BIS with end-tidal sevoflurane concentration in infants and children. Anesth Analg. 2000;90:872–7. http://dx.doi.org/10.1213/00000539-200004000-00018. - DOI - PubMed

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