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. 2016 Jun 18;9(6):858-62.
doi: 10.18240/ijo.2016.06.12. eCollection 2016.

Peripheral retinal non-perfusion and treatment response in branch retinal vein occlusion

Kaveh Abri Aghdam  1 , Lukas Reznicek  2 , Mostafa Soltan Sanjari  3 , Carsten Framme  1 , Anna Bajor  1 , Annemarie Klingenstein  2 , Marcus Kernt  2 , Florian Seidensticker  4
Affiliations

Peripheral retinal non-perfusion and treatment response in branch retinal vein occlusion

Kaveh Abri Aghdam et al. Int J Ophthalmol. .

Abstract

Aim: To evaluate the association between the size of peripheral retinal non-perfusion and the number of intravitreal ranibizumab injections in patients with treatment-naive branch retinal vein occlusion (BRVO) and macular edema.

Methods: A total of 53 patients with treatment-naive BRVO and macular edema were included. Each patient underwent a full ophthalmologic examination including optical coherence tomography (OCT) imaging and ultra wide-field fluorescein angiography (UWFA). Monthly intravitreal ranibizumab injections were applied according to the recommendations of the German Ophthalmological Society. Two independent, masked graders quantified the areas of peripheral retinal non-perfusion.

Results: Intravitreal injections improved best-corrected visual acuity (BCVA) significantly from 22.23±16.33 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters to 36.23±15.19 letters (P<0.001), and mean central subfield thickness significantly reduced from 387±115 µm to 321±115 µm (P=0.01). Mean number of intravitreal ranibizumab injections was 3.61±1.56. The size of retinal non-perfusion correlated significantly with the number of intravitreal ranibizumab injections (R=0.724, P<0.001).

Conclusion: Peripheral retinal non-perfusion in patients with BRVO associates significantly with intravitreal ranibizumab injections in patients with BRVO and macular edema.

Keywords: angiography; branch retinal vein occlusion; non-perfusion; retina; wide-field.

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Figures

Figure 1
Figure 1. En face wide-field fundus image of the right eye with BRVO.
Figure 2
Figure 2. Optos fluorescein angiogram of the same patient at arterio-venous (A) and late venous (B) phases
The late phase image reveals central fluorescein leakage inferior to the fovea and extensive areas of non-perfusion in the infero-temporal part of the peripheral fundus.
Figure 3
Figure 3. Quantification of the amount of non-perfused areas using the grid with 27×17 square fields approximately the size of the optic disc.
See this image and copyright information in PMC

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