Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jun 18;9(6):898-903.
doi: 10.18240/ijo.2016.06.19. eCollection 2016.

Radial optic neurotomy in treating central retinal vein occlusion: a Meta-analysis

Zhen-Na Chen  1 , Yan Shao  1 , Xiao-Rong Li  1
Affiliations

Radial optic neurotomy in treating central retinal vein occlusion: a Meta-analysis

Zhen-Na Chen et al. Int J Ophthalmol. .

Abstract

Aim: To assess the feasibility of radial optic neurotomy (RON) in central retinal vein occlusion (CRVO) treatment with a Meta-analysis.

Methods: Electronic databases were searched for comprehensive articles that compared efficacy of RON with that of other treatments in CRVO. Study quality was assessed and risk ratio (RR) and 95% confidence interval (CI) with fix- or random-effects model were calculated according to the heterogeneity.

Results: A total of 200 eyes from 5 studies were included. The results indicated that no significant differences were found between groups with and without RON in improvement of visual acuity (VA) at 6mo follow-up (pooled RR 0.51, 95%CI 0.22 to 1.18, P=0.117) while improvement of VA showed significantly favourable in patients receiving RON treatment at 12mo follow-up (pooled RR 2.27, 95%CI 1.31 to 3.95, P=0.004). For complications, RON treatment was more effective in reducing neovascular glaucoma (pooled RR 0.45, 95%CI 0.21 to 0.97, P=0.042) but was comparable in retinal detachment (pooled RR 2.41, 95%CI 0.51 to 11.39, P=0.267) and vitreous hemorrhage (pooled RR 0.91, 95%CI 0.33 to 2.46, P=0.847).

Conclusion: Compared with some certain treatment modalities, RON might offer better VA at 12mo and decrease the rate of neovascular glaucoma without changing the rate of retinal detachment and vitreous hemorrhage. Further studies are required considering the limitation of the research.

Keywords: Meta-analysis; central retinal vein occlusion; radial optic neurotomy.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Flow diagram of trial selection.
Figure 2
Figure 2. Meta-analysis of postoperative VA at 6mo follow-up.
Figure 3
Figure 3. Meta-analysis of postoperative VA at 12mo follow-up.
Figure 4
Figure 4. Meta-analysis of retinal detachment.
Figure 5
Figure 5. Meta-analysis of neovascular glaucoma.
Figure 6
Figure 6. Meta-analysis of vitreous hemorrhage.
See this image and copyright information in PMC

References

    1. Natural history and clinical management of central retinal vein occlusion. Arch Ophthalmol. 1997;115(4):486–491. - PubMed
    1. MacDonald D. The ABCs of RVO: a review of retinal venous occlusion. Clin Exp Optom. 2014;97(4):311–323. - PubMed
    1. Berker N, Batman C. Surgical treatment of central retinal vein occlusion. Acta Ophthalmol. 2008;86(3):245–252. - PubMed
    1. Opremcak EM, Bruce RA, Lomeo MD, Ridenour CD, Letson AD, Rehmar AJ. Radial optic neurotomy for central retinal vein occlusion: a retrospective pilot study of 11 consecutive cases. Retina. 2001;21(5):408–415. - PubMed
    1. Stoffelns BM, Kramann C, Hoffmann E. Radial optic neurotomy (RON) for central retinal vein occlusion. Klin Monbl Augenheilkd. 2007;224(4):282–287. - PubMed

LinkOut - more resources