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Review
. 2016 Aug:29:47-53.
doi: 10.1016/j.coph.2016.06.003. Epub 2016 Jun 28.

Vesicle-MaNiA: extracellular vesicles in liquid biopsy and cancer

Veronica Torrano  1 , Felix Royo  2 , Héctor Peinado  3 , Ana Loizaga-Iriarte  4 , Miguel Unda  4 , Juan M Falcón-Perez  5 , Arkaitz Carracedo  6
Affiliations
Review

Vesicle-MaNiA: extracellular vesicles in liquid biopsy and cancer

Veronica Torrano et al. Curr Opin Pharmacol. 2016 Aug.

Abstract

Normal and tumor cells shed vesicles to the environment. Within the large family of extracellular vesicles, exosomes and microvesicles have attracted much attention in the recent years. Their interest ranges from mediators of cancer progression, inflammation, immune regulation and metastatic niche regulation, to non-invasive biomarkers of disease. In this respect, the procedures to purify and analyze extracellular vesicles have quickly evolved and represent a source of variability for data integration in the field. In this review, we provide an updated view of the potential of exosomes and microvesicles as biomarkers and the available technologies for their isolation.

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Conflict of interest statement

The authors declare no conflict of interest

Figures

Figure 1
Figure 1. Schematic representation of extracellular vesicles (EVs) as biomarkers in liquid biopsy
The distinct composition of EVs and its cargo in normal and cancer cells is indicated by differential coloring. Shedding of EVs to blood and urine is depicted (note that urine accessibility will be organ-dependent). The potential of cancer-EVs to educate the pre-metastatic niche is represented as the accumulation of vesicles in target organs.
See this image and copyright information in PMC

References

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