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. 2016 Jul 1;11(7):e0156957.
doi: 10.1371/journal.pone.0156957. eCollection 2016.

Association between Serum Bilirubin and Acute Intraoperative Hyperglycemia Induced by Prolonged Intermittent Hepatic Inflow Occlusion in Living Liver Donors

Sangbin Han  1   2 , Sang-Man Jin  3 , Justin Sangwook Ko  1 , Young Ri Kim  1 , Mi Sook Gwak  1 , Hee Jeong Son  2 , Jae-Won Joh  4 , Gaab Soo Kim  1
Affiliations

Association between Serum Bilirubin and Acute Intraoperative Hyperglycemia Induced by Prolonged Intermittent Hepatic Inflow Occlusion in Living Liver Donors

Sangbin Han et al. PLoS One. .

Abstract

Background: Intermittent hepatic inflow occlusion (IHIO) is associated with acute hyperglycemia during living donor hepatectomy when the ischemia is prolonged. Bilirubin is a potent antioxidant to play an important role for maintaining insulin sensitivity and preventing hyperglycemia. Thus, we aimed to test whether serum bilirubin level is associated with prolonged IHIO-induced intraoperative hyperglycemia.

Methods: Seventy-five living liver donors who underwent a prolonged IHIO with a >30 minute cumulative ischemia were included. The association between preoperative serum bilirubin concentrations and the risk of intraoperative hyperglycemia (blood glucose concentration >180 mg/dl) was analyzed using binary logistic regression with adjusting for potential confounders including age and steatosis.

Results: The number of donors who underwent 3, 4, 5, and 6 rounds of IHIO was 41, 22, 7, and 5, respectively. Twenty-nine (35%) donors developed intraoperative hyperglycemia. Total bilirubin concentration was inversely associated with hyperglycemia risk (odds ratio [OR] 0.033, 95% confidence interval [CI] 0.004-0.313, P = 0.003). There was an interaction between age and total bilirubin concentration: the effect of lower serum total bilirubin (≤0.7 mg/dl) on the development of hyperglycemia was greater in older donors (>40 years) than in younger donors (P = 0.0.028 versus P = 0.212). Both conjugated bilirubin (OR 0.001 95% CI 0.001-0.684) and unconjugated bilirubin (OR 0.011 95% CI 0.001-0.246) showed an independent association with hyperglycemia risk.

Conclusions: Lower preoperative serum bilirubin was associated with greater risk of prolonged IHIO-induced hyperglycemia during living donor hepatectomy particularly in older donors. Thus, more meticulous glycemic management is recommended when prolonged IHIO is necessary for surgical purposes in old living donors with lower serum bilirubin levels.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Intraoperative blood glucose concentrations before the start of IHIO (B), during each clamping period (C), and during each unclamping period (U) in donors who developed intraoperative hyperglycemia and in donors without intraoperative hyperglycemia.
Circlet indicates the median and whiskers indicate the range.
Fig 2
Fig 2. Adjusted probability of intraoperative hyperglycemia in relation to serum total bilirubin level.
The number next to the arrow indicates the age (years) of each donor.
Fig 3
Fig 3. Interaction between serum bilirubin and age.
The impact of lower serum bilirubin on the development of intraoperative hyperglycemia is stronger in old donors (>40 years) than in younger donors.
See this image and copyright information in PMC

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