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Review
. 2016 Jun 29;17(7):1002.
doi: 10.3390/ijms17071002.

Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets

J Abraham Domínguez-Avila  1 , Gustavo A González-Aguilar  2 , Emilio Alvarez-Parrilla  3 , Laura A de la Rosa  4
Affiliations
Review

Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets

J Abraham Domínguez-Avila et al. Int J Mol Sci. .

Abstract

Peroxisome proliferator-activated receptors (PPAR) are transcription factors that modulate energy metabolism in liver, adipose tissue and muscle. High fat diets (HFD) can negatively impact PPAR expression or activity, favoring obesity, dyslipidemia, insulin resistance and other conditions. However, polyphenols (PP) found in vegetable foodstuffs are capable of positively modulating this pathway. We therefore focused this review on the possible effects that PP can have on PPAR when administered together with HFD. We found that PP from diverse sources, such as coffee, olives, rice, berries and others, are capable of inducing the expression of genes involved in a decrease of adipose mass, liver and serum lipids and lipid biosynthesis in animal and cell models of HFD. Since cells or gut bacteria can transform PP into different metabolites, it is possible that a synergistic or antagonistic effect ultimately occurs. PP molecules from vegetable sources are an interesting option to maintain or return to a state of energy homeostasis, possibly due to an adequate PPAR expression and activity.

Keywords: PPAR; gene expression; high fat; polyphenols.

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References

    1. Krey G., Braissant O., LHorset F., Kalkhoven E., Perroud M., Parker M.G., Wahli W. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol. Endocrinol. 1997;11:779–791. doi: 10.1210/mend.11.6.0007. - DOI - PubMed
    1. Braissant O., Foufelle F., Scotto C., Dauca M., Wahli W. Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α, -β, and -γ in the adult rat. Endocrinology. 1996;137:354–366. - PubMed
    1. Grygiel-Gorniak B. Peroxisome proliferator-activated receptors and their ligands: Nutritional and clinical implications—A review. Nutr. J. 2014;13 doi: 10.1186/1475-2891-13-17. - DOI - PMC - PubMed
    1. Hihi A.K., Michalik L., Wahli W. PPARs: Transcriptional effectors of fatty acids and their derivatives. Cell. Mol. Life Sci. 2002;59:790–798. doi: 10.1007/s00018-002-8467-x. - DOI - PMC - PubMed
    1. Youssef J.A., Badr M.Z. Tissue distribution and versatile functions of PPARS. In: Youssef A.J., Badr Z.M., editors. Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances. Humana Press; Totowa, NJ, USA: 2013. pp. 33–69.

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