Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2016 Sep;26(9):973-7.
doi: 10.1080/13543776.2016.1206527. Epub 2016 Jul 6.

Inhibitors of programmed cell death 1 (PD-1): a patent review (2010-2015)

Tryfon Zarganes-Tzitzikas  1 , Markella Konstantinidou  1 , Yongzhi Gao  1 , Dobroslawa Krzemien  2 , Krzysztof Zak  2 , Grzegorz Dubin  2 , Tad A Holak  2   3 , Alexander Dömling  1
Affiliations
Editorial

Inhibitors of programmed cell death 1 (PD-1): a patent review (2010-2015)

Tryfon Zarganes-Tzitzikas et al. Expert Opin Ther Pat. 2016 Sep.
No abstract available

Keywords: PD-1; PD-L1; Programmed death-1; T-cell exhaustion; immune checkpoint; immune-oncology.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Small-molecule antagonists of the PD-1 pathway.
Fig. 2
Fig. 2
PD-1/PD-L1 inhibitors synthesized by BMS.
Fig. 3
Fig. 3
False positive PD-1/PD-L1 inhibitors
Fig. 4
Fig. 4
Peptidomimetic inhibitors of the PD-1/PD-L1 interaction with oxa- and thiadiazole core moieties
Fig. 5
Fig. 5
a) Hydrolysis-resistant D-peptide antagonist to target the PD-1/PD-L1 b) Macrocyclic peptidic inhibitor c) Peptide antagonist of PD-L1 (10) along with its sequence similarities to PD-1
See this image and copyright information in PMC

References

    1. Dömling A, Holak TA. Programmed Death-1: Therapeutic Success after More than 100 Years of Cancer Immunotherapy. Angewandte Chemie International Edition. 2014;53:2286–88. - PMC - PubMed
    1. Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol. 2008;26:677–04. - PMC - PubMed
    1. Day CL, Kaufmann DE, Kiepiela P, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature. 2006;443:350–54. An excellent paper about PD-1 expression on human immunodeficiency virus (HIV)-specific CD8 T-cells. - PubMed
    1. Carvahlo S, Levi-Schaffer F, Sela M, Yarden Y. Immunotherapy of cancer: from monoclonal to oligoclonal cocktails of anti-cancer antibodies: IUPHAR Review X. Br J Pharmacol. 2016;173:1407–24. - PMC - PubMed
    1. Wolchok JD. PD-1 Blockers. Cell. 2015;162:937. - PubMed

Publication types