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. 2016 Jun;95(26):e4016.
doi: 10.1097/MD.0000000000004016.

Association between psychiatric disorders and osteoarthritis: a nationwide longitudinal population-based study

Shih-Wei Huang  1 , Wei-Te Wang, Li-Fong Lin, Chun-De Liao, Tsan-Hon Liou, Hui-Wen Lin
Affiliations

Association between psychiatric disorders and osteoarthritis: a nationwide longitudinal population-based study

Shih-Wei Huang et al. Medicine (Baltimore). 2016 Jun.

Abstract

Although the association between depressive disorders and osteoarthritis (OA) has been studied, the association of other psychiatric disorders with OA remains unclear. Here, we investigated whether psychiatric disorders are risk factors for OA.The data were obtained from the Longitudinal Health Insurance Database 2005 of Taiwan. We collected the ambulatory care claim records of patients who were diagnosed with psychiatric disorders according to the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes between January 1, 2004 and December 31, 2008. The prevalence and adjusted hazard ratios (HRs) of osteoarthritis among patients with psychiatric disorders and the control cohort were estimated.Of 74,393 patients with psychiatric disorders, 16,261 developed OA during the 7-year follow-up period. The crude HR for OA was 1.44 (95% confidence interval [CI], 1.39-1.49), which was higher than that of the control cohort. The adjusted HR for OA was 1.42 (95% CI, 1.39-1.42) among patients with psychiatric disorders during the 7-year follow-up period. Further analysis revealed that affective psychoses, neurotic illnesses or personality disorders, alcohol and drug dependence or abuse, and other mental disorders were risk factors for OA.This large-scale longitudinal population-based study revealed that affective psychoses, personality disorders, and alcohol and drug dependence or abuse are risk factors for OA.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flowchart diagram of data collection.
Figure 2
Figure 2
A hazard-rates plot of the Kaplan–Meier method for osteoarthritis in psychiatric disorder patients and the controls during the follow-up period of up to 7 years.
Figure 3
Figure 3
Hazard-rates plot of the Kaplan–Meier method for osteoarthritis in schizophrenia, affective psychosis, paranoid status and nonorganic psychoses, neurotic illness or personality disorders, alcohol and drug dependence or misuse, and other mental disorders patients and the controls during the follow-up period of up to 7 years.
See this image and copyright information in PMC

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