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Comment
. 2016 Jun 30;166(1):9-10.
doi: 10.1016/j.cell.2016.06.035.

Mitochondrial Networking in T Cell Memory

Marc Liesa  1 , Orian S Shirihai  2
Affiliations
Free article
Comment

Mitochondrial Networking in T Cell Memory

Marc Liesa et al. Cell. .
Free article

Abstract

T-lymphocytes show large changes in ATP demand and nutrient utilization, imposed by their different roles as T memory and T effector cells. Therefore, T cell remodeling represents a bioenergetic challenge to mitochondria. New work from Buck et al. links changes in mitochondrial shape to T cell fate choice.

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  • Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.
    Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL. Buck MD, et al. Cell. 2016 Jun 30;166(1):63-76. doi: 10.1016/j.cell.2016.05.035. Epub 2016 Jun 9. Cell. 2016. PMID: 27293185 Free PMC article.

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