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. 2016 Jul-Sep;10(3):301-7.
doi: 10.4103/1658-354X.174907.

Comparative effect of propofol versus sevoflurane on renal ischemia/reperfusion injury after elective open abdominal aortic aneurysm repair

A S Ammar  1 , K M Mahmoud  1
Affiliations

Comparative effect of propofol versus sevoflurane on renal ischemia/reperfusion injury after elective open abdominal aortic aneurysm repair

A S Ammar et al. Saudi J Anaesth. 2016 Jul-Sep.

Abstract

Background: Renal injury is a common cause of morbidity and mortality after elective abdominal aortic aneurysm (AAA) repair. Propofol has been reported to protect several organs from ischemia/reperfusion (I/R) induced injury. We performed a randomized clinical trial to compare propofol and sevoflurane for their effects on renal I/R injury in patients undergoing elective AAA repair.

Materials and methods: Fifty patients scheduled for elective AAA repair were randomized to receive propofol anesthesia in group I or sevoflurane anesthesia in group II. Urinary specific kidney proteins (N-acetyl-beta-glucosamidase, alpha-1-microglobulin, glutathione transferase [GST]-pi, GST-alpha) were measured within 5 min of starting anesthesia as a base line (T0), at the end of surgery (T1), 8 h after surgery (T2), 16 h after surgery (T3), and 24 h postoperatively (T4). Serum pro-inflammatory cytokines (tumor necrosis factor-α and interleukin 1-β) were measured at the same time points. In addition, serum creatinine and cystatin C were measured before starting surgery as a baseline and at days 1, 3, and 6 after surgery.

Results: Postoperative urinary concentrations of all measured kidney specific proteins and serum pro-inflammatory cytokines were significantly lower in the propofol group. In addition, the serum creatinine and cystatin C were significantly lower in the propofol group compared with the sevoflurane group.

Conclusion: Propofol significantly reduced renal injury after elective open AAA repair and this could have clinical implications in situations of expected renal I/R injury.

Keywords: Propofol; renal ischemia-reperfusion injury; sevoflurane.

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References

    1. Diehl JT, Cali RF, Hertzer NR, Beven EG. Complications of abdominal aortic reconstruction. An analysis of perioperative risk factors in 557 patients. Ann Surg. 1983;197:49–56. - PMC - PubMed
    1. Brady AR, Fowkes FG, Greenhalgh RM, Powell JT, Ruckley CV, Thompson SG. Risk factors for postoperative death following elective surgical repair of abdominal aortic aneurysm: Results from the UK small aneurysm trial. On behalf of the UK small aneurysm trial participants. Br J Surg. 2000;87:742–9. - PubMed
    1. Wald R, Waikar SS, Liangos O, Pereira BJ, Chertow GM, Jaber BL. Acute renal failure after endovascular vs open repair of abdominal aortic aneurysm. J Vasc Surg. 2006;43:460–6. - PubMed
    1. Gamulin Z, Forster A, Morel D, Simonet F, Aymon E, Favre H. Effects of infrarenal aortic cross-clamping on renal hemodynamics in humans. Anesthesiology. 1984;61:394–9. - PubMed
    1. Welch M, Knight DG, Carr HM, Smyth JV, Walker MG. Influence of renal artery blood flow on renal function during aortic surgery. Surgery. 1994;115:46–51. - PubMed