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. 2016 Jun 8:8:132.
doi: 10.3389/fnagi.2016.00132. eCollection 2016.

Older Candidates for Subthalamic Deep Brain Stimulation in Parkinson's Disease Have a Higher Incidence of Psychiatric Serious Adverse Events

Vitalii V Cozac  1 , Michael M Ehrensperger  2 , Ute Gschwandtner  1 , Florian Hatz  1 , Antonia Meyer  1 , Andreas U Monsch  2 , Michael Schuepbach  3 , Ethan Taub  1 , Peter Fuhr  1
Affiliations

Older Candidates for Subthalamic Deep Brain Stimulation in Parkinson's Disease Have a Higher Incidence of Psychiatric Serious Adverse Events

Vitalii V Cozac et al. Front Aging Neurosci. .

Abstract

Objective: To investigate the incidence of serious adverse events (SAE) of subthalamic deep brain stimulation (STN-DBS) in elderly patients with Parkinson's disease (PD).

Methods: We investigated a group of 26 patients with PD who underwent STN-DBS at mean age 63.2 ± 3.3 years. The operated patients from the EARLYSTIM study (mean age 52.9 ± 6.6) were used as a comparison group. Incidences of SAE were compared between these groups.

Results: A higher incidence of psychosis and hallucinations was found in these elderly patients compared to the younger patients in the EARLYSTIM study (p < 0.01).

Conclusions: The higher incidence of STN-DBS-related psychiatric complications underscores the need for comprehensive psychiatric pre- and postoperative assessment in older DBS candidates. However, these psychiatric SAE were transient, and the benefits of DBS clearly outweighed its adverse effects.

Keywords: Parkinson's disease (PD); adverse events; age factors; deep brain stimulation (DBS); psychosis.

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References

    1. Appleby B. S., Duggan P. S., Regenberg A., Rabins P. V. (2007). Psychiatric and neuropsychiatric adverse events associated with deep brain stimulation: a meta-analysis of ten years' experience. Mov. Disord. 22, 1722–1728. 10.1002/mds.21551 - DOI - PubMed
    1. Bellomo R., Warillow S. J., Reade M. C. (2009). Why we should be wary of single-center trials. Crit. Care Med. 37, 3114–3119. 10.1097/CCM.0b013e3181bc7bd5 - DOI - PubMed
    1. Bickel S., Alvarez L., Macias R., Pavon N., Leon M., Fernandez C., et al. . (2010). Cognitive and neuropsychiatric effects of subthalamotomy for Parkinson's disease. Parkinsonism Relat. Disord. 16, 535–539. 10.1016/j.parkreldis.2010.06.008 - DOI - PubMed
    1. Daniele A., Spinelli P., Piccininni C. (2012). Cognitive and behavioural changes after deep brain stimulation of the subthalamic nucleus in Parkinson's disease, in Explicative Cases of Controversial Issues in Neurosurgery, ed Signorelli F. (Rijeka: InTech; ), 385–415.
    1. Drevets W. C., Price J. L., Simpson J. R., Todd R. D., Reich T, Vannier M., et al. . (1997). Subgenual prefrontal cortex abnormalities in mood disorders. Nature 386, 824–827. 10.1038/386824a0 - DOI - PubMed