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Comment
. 2016 Aug 15;35(16):1724-5.
doi: 10.15252/embj.201695080. Epub 2016 Jul 4.

Cloud storage for endosomes

Teegan Dellibovi-Ragheb  1 , Nihal Altan-Bonnet  1
Affiliations
Comment

Cloud storage for endosomes

Teegan Dellibovi-Ragheb et al. EMBO J. .

Abstract

Coordinated regulation of vesicle trafficking is critical for the proper functioning of a cell. The bulk of cellular transport vesicles are sequestered in a “perinuclear cloud”, with only a small fraction released to the cell periphery. Jongsma et al (2016) found that the ER‐associated E3 ubiquitin ligase RNF26 is responsible for establishing and maintaining the architecture of the perinuclear cloud and that this spatiotemporal positioning is critical for effective regulation of the endocytic and exocytic systems.

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Figures

Figure 1
Figure 1. RNF26 establishes and maintains the architecture of the perinuclear cloud
(A) Transport vesicles from both the endocytic and exocytic pathways cluster in a perinuclear cloud closely associated with the endoplasmic reticulum (ER). These vesicles include early endosomes, late endosomes/MVBs, lysosomes, and post‐Golgi secretory vesicles. (B) The ER‐associated E3 ubiquitin ligase RNF26 recruits and ubiquitinates the SQSTM1 scaffold protein. This provides a docking platform for vesicle‐associated adaptor molecules and tethers these vesicles to the perinuclear region of the ER. Vesicles are released through the action of the deubiquitinating enzyme USP15.
See this image and copyright information in PMC

Comment on

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