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. 1989 Jun;108(6):2083-92.
doi: 10.1083/jcb.108.6.2083.

Primary structure analysis of an integral membrane glycoprotein of the nuclear pore

R W Wozniak  1 , E Bartnik, G Blobel
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Primary structure analysis of an integral membrane glycoprotein of the nuclear pore

R W Wozniak et al. J Cell Biol. 1989 Jun.

Abstract

The complete primary structure of an integral membrane glycoprotein of the nuclear pore was deduced from the cDNA sequence. The cDNA encodes a polypeptide of 204,205 D containing a 25-residue-long signal sequence, two hydrophobic segments that could function as transmembrane segments, and 13 potential N-linked oligosaccharide addition sites. Endoglycosidase H reduces the molecular mass by approximately 9 kD suggesting that not all of these 13 sites are used. We discuss possible models for the topology of this protein in the pore membrane as well as a possible role in the formation of pores and pore complexes.

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References

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