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Review
. 2016 May;64(5):332-6.
doi: 10.4103/0301-4738.185585.

Genetic perspective of retinoblastoma: From present to future

Madhavan Jagadeesan  1 , Vikas Khetan  2 , Ashwin Mallipatna  3
Affiliations
Review

Genetic perspective of retinoblastoma: From present to future

Madhavan Jagadeesan et al. Indian J Ophthalmol. 2016 May.

Abstract

Retinoblastoma (RB) is the most common malignant intraocular tumor in children. In the last decade, basic research has led to a better understanding of events after two hits in RB susceptibility gene (RB1), molecular mechanism of tumor growth, the cell of origin of RB, etc. This would pave way to identify biomarkers and molecular targeted therapy for better treatment option in the future. Furthermore, improvement in molecular techniques has led to enhanced diagnostic methods for early diagnosis, genetic counseling, and prevention of the disease. This review will help to understand the essence of basic research work conducted in recent times and its implication in the management of RB in the future.

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Figures

Figure 1
Figure 1
Events that leads to the progression of retinoblastoma
See this image and copyright information in PMC

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