Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 May;64(5):358-63.
doi: 10.4103/0301-4738.185594.

Lamina depth and thickness correlate with glaucoma severity

Affiliations

Lamina depth and thickness correlate with glaucoma severity

Martha Kim et al. Indian J Ophthalmol. 2016 May.

Abstract

Purpose: To evaluate the correlation between lamina cribrosa (LC) morphology and glaucoma severity in patients with primary forms of open-angle glaucoma (OAG) using enhanced depth imaging spectral-domain optical coherence tomography (SD-OCT) and Humphrey visual field test (HVF).

Subjects and methods: Patients with OAG (n = 166), divided into normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) groups (n = 66 and n = 100), were imaged using SD-OCT to obtain horizontal B-scan images of the optic nerve head (ONH). Laminar depth (LD) and laminar thickness (LT) were measured at the center of ONH.

Results: The mean (±standard deviation) values of LD, LT, and visual field mean deviation (MD) were 555.4 ± 142.3 μm, 179.9 ± 49.7 μm, and - 5.7 ± 6.4 dB, respectively. In the multivariate linear regression analysis, LD, LT, and intraocular pressure (IOP) were significantly correlated with MD (P = 0.007, P = 0.037, and P = 0.004, respectively). In the subgroup analyses, only LD was associated with MD in the NTG group (n = 66), whereas LT and IOP were correlated with MD in the HTG group (n = 100). Neither axial length nor central corneal thickness was associated with LD or LT.

Conclusions: Glaucoma severity, as measured by HVF MD, shows significant correlations with LD and LT, with greater severity associated with increasing LD and decreasing LT. Normal- and high-tension OAG patients have different associations with LD and LT, which implies that the pathogenesis of these two entities might be different.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Representative reference planes (white-dotted lines) and lamina cribrosa (white lines). Infrared images (left column) show the radial section where the horizontal cross-sectional B-scans (right column) were acquired. (a) Example of the reference plane (white-dotted line) with clear Bruch's membrane termination (white arrow). (b) Example of unclear Bruch's membrane termination with border tissue (black arrowheads). The imaginary extension of the line along with the Bruch's membrane surface is used as reference plane (white-dotted line)

References

    1. Allingham RR, Damji KF, Freedman SF, Moroi SE, Rhee DJ. Shields Textbook of Glaucoma. 6th ed. Philadelphia: Lippincott Williams and Wilkins, Wolters Kluwer; 2011.
    1. Quigley HA, Addicks EM, Green WR, Maumenee AE. Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage. Arch Ophthalmol. 1981;99:635–49. - PubMed
    1. Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, et al. Optical coherence tomography. Science. 1991;254:1178–81. - PMC - PubMed
    1. Srinivasan VJ, Adler DC, Chen Y, Gorczynska I, Huber R, Duker JS, et al. Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head. Invest Ophthalmol Vis Sci. 2008;49:5103–10. - PMC - PubMed
    1. Inoue R, Hangai M, Kotera Y, Nakanishi H, Mori S, Morishita S, et al. Three-dimensional high-speed optical coherence tomography imaging of lamina cribrosa in glaucoma. Ophthalmology. 2009;116:214–22. - PubMed