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. 2016 May;64(5):358-63.
doi: 10.4103/0301-4738.185594.

Lamina depth and thickness correlate with glaucoma severity

Martha Kim  1 , Karine D Bojikian  2 , Mark A Slabaugh  2 , Leona Ding  2 , Philip P Chen  2
Affiliations

Lamina depth and thickness correlate with glaucoma severity

Martha Kim et al. Indian J Ophthalmol. 2016 May.

Abstract

Purpose: To evaluate the correlation between lamina cribrosa (LC) morphology and glaucoma severity in patients with primary forms of open-angle glaucoma (OAG) using enhanced depth imaging spectral-domain optical coherence tomography (SD-OCT) and Humphrey visual field test (HVF).

Subjects and methods: Patients with OAG (n = 166), divided into normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) groups (n = 66 and n = 100), were imaged using SD-OCT to obtain horizontal B-scan images of the optic nerve head (ONH). Laminar depth (LD) and laminar thickness (LT) were measured at the center of ONH.

Results: The mean (±standard deviation) values of LD, LT, and visual field mean deviation (MD) were 555.4 ± 142.3 μm, 179.9 ± 49.7 μm, and - 5.7 ± 6.4 dB, respectively. In the multivariate linear regression analysis, LD, LT, and intraocular pressure (IOP) were significantly correlated with MD (P = 0.007, P = 0.037, and P = 0.004, respectively). In the subgroup analyses, only LD was associated with MD in the NTG group (n = 66), whereas LT and IOP were correlated with MD in the HTG group (n = 100). Neither axial length nor central corneal thickness was associated with LD or LT.

Conclusions: Glaucoma severity, as measured by HVF MD, shows significant correlations with LD and LT, with greater severity associated with increasing LD and decreasing LT. Normal- and high-tension OAG patients have different associations with LD and LT, which implies that the pathogenesis of these two entities might be different.

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Figures

Figure 1
Figure 1
Representative reference planes (white-dotted lines) and lamina cribrosa (white lines). Infrared images (left column) show the radial section where the horizontal cross-sectional B-scans (right column) were acquired. (a) Example of the reference plane (white-dotted line) with clear Bruch's membrane termination (white arrow). (b) Example of unclear Bruch's membrane termination with border tissue (black arrowheads). The imaginary extension of the line along with the Bruch's membrane surface is used as reference plane (white-dotted line)
See this image and copyright information in PMC

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