[Adult Celiac Disease]

Abstract

Celiac disease is an immune-mediated enteropathy in genetically predisposed individuals, triggered by gluten ingestion. Clinical manifestations include intestinal and extraintestinal symptoms. Affected individuals may also be completely asymptomatic. Nevertheless, an early diagnosis is essential in order to prevent long-term complications. Diagnostic approach involves serologic testing for tissue transglutaminase antibodies followed by duodenal biopsy in case of seropositivity. Until now, the only available treatment consists of a strict glute-free diet. Newer therapeutic strategies are currently being evaluated in clinical trials.

Keywords: Gluten; HLA-DQ2/DQ8 - Gewebs-Transglutaminase-Antikörper; HLA-DQ2/DQ8 - tissue transglutaminase antibodies; Zöliakie; celiac disease; gluten.