Role of hepatic macrophages in alcoholic liver disease
- PMID: 27382116
- PMCID: PMC5495184
- DOI: 10.1136/jim-2016-000210
Role of hepatic macrophages in alcoholic liver disease
Abstract
Alcohol consumption can lead to the increase in gut permeability and cause the translocation of bacteria-derived lipopolysaccharides from the gut to the liver, which subsequently activates immune responses. In this process, macrophages play a critical role and involve in the pathogenesis of alcoholic liver disease (ALD). To define the mechanism underpinning the function of macrophages, it is important to conduct extensive studies to further explicate the phenotypic diversity of macrophages in the context of ALD. In this review, the role of hepatic macrophages in the pathogenesis of ALD is discussed.
Keywords: Liver Diseases, Alcoholic; Macrophages.
Copyright © 2016 American Federation for Medical Research.
Conflict of interest statement
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References
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- Marmier S, Dentin R, Daujat-Chavanieu M, et al. Novel role for ChREBP in the control of ethanol metabolism and susceptibility to binge drinking. Hepatology. 2015;62:1086–100. - PubMed
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