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Case Reports
. 2016 Jun;19(2):218-21.
doi: 10.4048/jbc.2016.19.2.218. Epub 2016 Jun 24.

Experience with Bilateral Risk-Reducing Mastectomy for an Unaffected BRCA Mutation Carrier

Yurina Maeshima  1 , Kumiko Oseto  1 , Ryohei Katsuragi  1 , Yukiko Yoshimoto  1 , Sachiko Takahara  1 , Akira Yamauchi  1
Affiliations
Case Reports

Experience with Bilateral Risk-Reducing Mastectomy for an Unaffected BRCA Mutation Carrier

Yurina Maeshima et al. J Breast Cancer. 2016 Jun.

Abstract

Women with BRCA1/2 mutations have a high risk of breast cancer and may opt for risk-reducing mastectomy (RRM). We report a 38-year-old Japanese woman who was diagnosed as a BRCA2 mutation carrier. She underwent prophylactic bilateral skin-sparing mastectomy (SSM) with excision of the nipple and preservation of the areola skin. It is unclear whether a bilateral RRM leads to better survival compared with intensive surveillance. The oncological risk associated with the presence of remnant breast glandular tissue after SSM or nipple-sparing mastectomy has been obscure. We report the first case of RRM for a Japanese BRCA mutation carrier and provide a literature review on risk management for BRCA mutation carriers with a focus on the concepts and procedures of RRM.

Keywords: BRCA2; Genes; Prophylactic surgical procedure; Subcutaneous mastectomy.

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Conflict of interest statement

CONFLICT OF INTEREST: The authors declare that they have no competing interests.

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