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Meta-Analysis
. 2016 Jul 4;49(7):e5149.
doi: 10.1590/1414-431X20165149.

Meta-analysis of the efficacy of proton pump inhibitors for the symptoms of laryngopharyngeal reflux

C Liu  1 , H Wang  2 , K Liu  3
Affiliations
Meta-Analysis

Meta-analysis of the efficacy of proton pump inhibitors for the symptoms of laryngopharyngeal reflux

C Liu et al. Braz J Med Biol Res. .

Abstract

The objective of this study was to perform a systematic review and meta-analysis to assess the effectiveness of proton pump inhibitors (PPI) for reflux disease in adult patients with laryngopharyngeal symptoms. A comprehensive search of Cochrane Library, EMBASE, Ovid EBM Reviews, and PubMed was performed for English-language literature about laryngopharyngeal reflux (LPR), in September 2014. The papers were filtered using pre-defined inclusion and exclusion criteria. Eight papers were identified and included in this meta-analysis. The sample comprised a pooled total of 370 patients, of which 210 and 160 patients took PPIs and placebo, respectively. The difference between PPIs and placebo groups in overall improvement of symptoms in adult patients with LPR was not statistically significant (RR=1.22; 95%CI=0.93-1.58; P=0.149). The difference in cough improvement was also not significant between PPIs and placebo groups (RR=0.65; 95%CI=0.30-1.41; P=0.279).

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Figures

Figure 1
Figure 1. Study selection process.
Figure 2
Figure 2. Forest plot showing the effect of PPIs on improvement in LPR symptoms. See Table 1 for reference details.
Figure 3
Figure 3. Forest plot showing the effect of PPIs on cough improvement. See Table 1 for reference details.
See this image and copyright information in PMC

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