Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2016 Jun;161(2):288-91.
doi: 10.1007/s10517-016-3397-z. Epub 2016 Jul 7.

Comparative Evaluation of β-Catenin and E-Cadherin Expression in Liquid Aspiration Biopsy Specimens of Thyroid Nodules

A V Isaeva  1   2 , A P Zima  3   4 , T V Saprina  3 , K T Kasoyan  5 , O S Popov  3 , O V Brynova  6 , I S Berezkina  3 , O A Vasil'eva  3 , N V Ryazantseva  7   8 , I P Shabalova  5 , L S Litvinova  4 , Yu D Pak  9 , V V Novitskii  3
Affiliations
Comparative Study

Comparative Evaluation of β-Catenin and E-Cadherin Expression in Liquid Aspiration Biopsy Specimens of Thyroid Nodules

A V Isaeva et al. Bull Exp Biol Med. 2016 Jun.

Abstract

We compared the results of gene molecular and immunocytochemical studies of β-catenin and E-cadherin in different variants of nodular thyroid disease (nodular colloid goiter, follicular thyroid adenocarcinoma, papillary thyroid cancer) and revealed changes of the function of the E-cadherin/β-catenin complex leading to switching from adhesion function of β-catenin in nodular colloid goiter to predominantly transcriptional activity in papillary carcinoma. The results confirm the important role of disturbances in E-cadherin-β-catenin interactions in the mechanisms of malignant transformation of follicular epithelium.

Keywords: E-cadherin; thyroid cancer; β-catenin.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources