Uncoupling proteins of invertebrates: A review
- PMID: 27385510
- DOI: 10.1002/iub.1535
Uncoupling proteins of invertebrates: A review
Abstract
Uncoupling proteins (UCPs) mediate inducible proton conductance in the mitochondrial inner membrane. Herein, we summarize our knowledge regarding UCPs in invertebrates. Since 2001, the presence of UCPs has been demonstrated in nematodes, mollusks, amphioxi, and insects. We discuss the following important issues concerning invertebrate UCPs: their evolutionary relationships, molecular and functional properties, and physiological impact. Evolutionary analysis indicates that the branch of vertebrate and invertebrate UCP4-5 diverged early in the evolutionary process prior to the divergence of the animal groups. Several proposed physiological roles of invertebrate UCPs are energy control, metabolic balance, and preventive action against oxidative stress. © 2016 IUBMB Life, 68(9):691-699, 2016.
Keywords: energy dissipation; insects; invertebrates; mitochondria; uncoupling proteins.
© 2016 International Union of Biochemistry and Molecular Biology.
Similar articles
-
Evolution of mitochondrial uncoupling proteins: novel invertebrate UCP homologues suggest early evolutionary divergence of the UCP family.FEBS Lett. 2005 Jan 17;579(2):313-7. doi: 10.1016/j.febslet.2004.11.103. FEBS Lett. 2005. PMID: 15642337
-
Functional characterization of the mitochondrial uncoupling proteins from the white shrimp Litopenaeus vannamei.Biochim Biophys Acta Bioenerg. 2020 Aug 1;1861(8):148209. doi: 10.1016/j.bbabio.2020.148209. Epub 2020 Apr 16. Biochim Biophys Acta Bioenerg. 2020. PMID: 32305415
-
Mitochondrial uncoupling proteins and phylogenesis--UCP4 as the ancestral uncoupling protein.FEBS Lett. 2001 Apr 27;495(3):137-41. doi: 10.1016/s0014-5793(01)02338-9. FEBS Lett. 2001. PMID: 11334880
-
Uncoupling proteins as a therapeutic target for the development of new era drugs against neurodegenerative disorder.Biomed Pharmacother. 2022 Mar;147:112656. doi: 10.1016/j.biopha.2022.112656. Epub 2022 Jan 25. Biomed Pharmacother. 2022. PMID: 35091238 Review.
-
The conserved regulation of mitochondrial uncoupling proteins: From unicellular eukaryotes to mammals.Biochim Biophys Acta Bioenerg. 2017 Jan;1858(1):21-33. doi: 10.1016/j.bbabio.2016.10.003. Epub 2016 Oct 14. Biochim Biophys Acta Bioenerg. 2017. PMID: 27751905 Review.
Cited by
-
Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function.Commun Biol. 2024 Oct 17;7(1):1342. doi: 10.1038/s42003-024-07042-3. Commun Biol. 2024. PMID: 39420071 Free PMC article.
-
Alteration of mitochondrial function in arthropods during arboviruses infection: a review of the literature.Front Physiol. 2025 Feb 13;16:1507059. doi: 10.3389/fphys.2025.1507059. eCollection 2025. Front Physiol. 2025. PMID: 40017802 Free PMC article. Review.
-
Mitochondrial electron transport chain, ROS generation and uncoupling (Review).Int J Mol Med. 2019 Jul;44(1):3-15. doi: 10.3892/ijmm.2019.4188. Epub 2019 May 8. Int J Mol Med. 2019. PMID: 31115493 Free PMC article.
-
Antioxidants, oxidative stress and reactive oxygen species in insects exposed to heat.Curr Res Insect Sci. 2025 May 22;7:100114. doi: 10.1016/j.cris.2025.100114. eCollection 2025. Curr Res Insect Sci. 2025. PMID: 40519244 Free PMC article. Review.
-
Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers.Int J Mol Sci. 2020 Aug 22;21(17):6052. doi: 10.3390/ijms21176052. Int J Mol Sci. 2020. PMID: 32842667 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
