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Randomized Controlled Trial
. 2017 Jun;57(6):831-838.
doi: 10.23736/S0022-4707.16.06235-6. Epub 2016 Jul 6.

Homeostasis Model Assessment-Adiponectin: the role of different types of physical exercise in obese adolescents

Raquel M da Silveira Campos  1   2 , Deborah C Landi Masquio  3 , Flávia Campos Corgosinho  3 , Priscila de Lima Sanches  3 , Aline de Piano  4 , June Carnier  3 , Patrícia Leão da Silva  5 , Ana P Grotti Clemente  6 , Sofia E de Castro Ferreira Vicente  3 , Lila M Oyama  3 , Claudia M da Penha Oller do Nascimento  3 , Lian Tock  7 , Sergio Tufik  8 , Marco T de Mello  3   8   9 , Ana R Dâmaso  3
Affiliations
Randomized Controlled Trial

Homeostasis Model Assessment-Adiponectin: the role of different types of physical exercise in obese adolescents

Raquel M da Silveira Campos et al. J Sports Med Phys Fitness. 2017 Jun.

Abstract

Background: Homeostasis Model Assessment-Adiponectin (HOMA-AD) is suggesting a new biomarker of insulin resistance in obese population. In this way, the purpose of this study was to investigate the effects of different kinds of exercise in the sensitive index predictor of insulin resistance.

Methods: A total of 148 obese adolescents were enrolled in the program. They aged 15-19 y, with Body Mass Index (BMI) ≥P95th and were submitted to 1 year of interdisciplinary weight loss therapy, randomized in two groups, aerobic training (AT) (N.=51) and aerobic plus resistance training (N.=97). Blood samples were collected to analyze adiponectin, glucose and insulin concentrations. The insulin resistance was measured by HOMA-AD and Homeostasis Model Assessment Insulin Resistance Index (HOMA-IR).

Results: Both kinds of exercise training promoted a decrease in body mass, body mass index, fat mass, visceral and subcutaneous fat. However, only aerobic plus resistance training was effective to reduce HOMA-AD, insulin and glucose concentration; and increase insulin sensibility and adiponectin concentration.

Conclusions: The aerobic plus resistance training was more effective than AT alone to improve the HOMA-AD, suggesting clinical application on obesity, diabetes, atherosclerosis and metabolic syndrome control in the pediatric population.

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