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. 2016 Jul-Aug;36(4):457-9.
doi: 10.3747/pdi.2015.00169.

Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags

Farzana Yousaf  1 , Syed T R Zaidi  1 , Troy Wanandy  2 , Matthew D Jose  3 , Rahul P Patel  4
Affiliations

Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags

Farzana Yousaf et al. Perit Dial Int. 2016 Jul-Aug.

Abstract

Intraperitoneal cefepime is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by gram-negative bacteria. The current study investigated the stability of cefepime in a pH-neutral PD solution. A reconstituted solution of cefepime was injected into a total of 9 PD bags and stored at 4°C, 25°C or 37°C for various time points. Cefepime retained more than 90% of its initial concentration for 168, 96, and 12 hours at 4°C, 25°C and 37°C, respectively. No apparent physical precipitation or pH change was observed during the study. This study provides crucial information to healthcare professionals on the physical and chemical stability of cefepime in the pH-neutral solution to help them in preparing such admixtures in advance where required.

Keywords: Cefepime; compatibility; pH neutral; peritoneal dialysis; peritonitis; stability.

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