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. 2016 Jul;7(4):508-11.
doi: 10.1111/1759-7714.12341. Epub 2016 Feb 25.

Pulmonary sclerosing pneumocytoma mimicking lung cancer: Case report and review of the literature

Jung-Hwan Lim  1 , Nuri Lee  2 , Dae-Woong Choi  2 , Hyung-Joo Oh  1 , Ha Young Park  1 , Ki-Hyun Kim  1 , Tae-Ok Kim  3 , Cheol-Kyu Park  3 , Hong-Jun Shin  1 , Yoo-Duk Choi  4 , Ju-Sik Yun  5 , Sang-Yun Song  5 , In-Jae Oh  3
Affiliations

Pulmonary sclerosing pneumocytoma mimicking lung cancer: Case report and review of the literature

Jung-Hwan Lim et al. Thorac Cancer. 2016 Jul.

Abstract

Pulmonary sclerosing pneumocytoma (PSP) is a rare benign neoplasm that predominantly affects middle-aged Asian women. PSP is often asymptomatic and demonstrates a solitary pulmonary nodule on radiologic examination. We report a case of PSP initially misdiagnosed as lung cancer because of strong (18)F-fluorodeoxyglucose (FDG) uptake revealed by (18)F-FDG positron emission tomography-computed tomography scan. After surgery, pathology revealed that the tumor cells were immunopositive for epithelial membrane antigen and thyroid transcription factor-1. The patient has been followed up without complication or recurrence.

Keywords: Positron emission tomography; pulmonary sclerosing hemangioma; solitary pulmonary nodule.

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Figures

Figure 1
Figure 1
(a) Computed tomography (CT) obtained at another hospital during percutaneous needle biopsy shows a 1.5 cm round nodule in the left lower lobe, adjacent to the left cardiac border. (b) CT performed six months later revealed a slightly increased nodule diameter of 2 cm. (c) The nodule was solitary, well‐circumscribed, and round‐shaped in the anteromediobasal segment of the left lower lobe. (d) 18F‐ fluorodeoxyglucose (FDG) positron emission tomography‐CT revealed high FDG uptake (maximum standardized uptake value = 3.9) at the nodule without regional or distant metastasis.
Figure 2
Figure 2
After surgical resection, a solid, yellow mass about 2.5 cm in size was separated by normal lung parenchyma.
Figure 3
Figure 3
(a) A well‐demarcated solid mass was easily separated by normal lung parenchyma (hematoxylin and eosin [H&E], × 20). (b) The hemorrhagic mass is situated in the sub‐bronchial area (H&E, × 40). (c) Focal sclerotic change was shown within the tumor (H&E, × 100). (d) The tumor was composed of monotonous, round tumor cells covered by hyperchromatic spindle cells (H&E, × 400). (e) Immunohistochemical staining detected epithelial membrane antigen in the surface of the tumor cells, but not in the round cells (× 100). (f) Thyroid transcription factor‐1 was detected in both the surface tumor cells and the round cells (× 100).
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References

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