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Review
. 2016 Jul;77(7):403-8.
doi: 10.12968/hmed.2016.77.7.403.

Digital clubbing: forms, associations and pathophysiology

Simon Dubrey  1 , Shrestha Pal  2 , Sarneet Singh  3 , Georgios Karagiannis  4
Affiliations
Review

Digital clubbing: forms, associations and pathophysiology

Simon Dubrey et al. Br J Hosp Med (Lond). 2016 Jul.

Abstract

Among proposed mechanisms to explain digital clubbing, the release of cytokines, specifically vascular endothelial growth factor and platelet-derived growth factor, from aggregated platelets and megakaryocytes has emerged as the most likely explanation. This review describes these and other contributory processes.

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