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. 1978 Feb 18;7(7):525-8.

[Leukaemias and lymphomas treatment by vindesine. Result of a phase II trial in terms of remission induction (author's transl)]

[Article in French]
G Marthé, J L Misset, F de Vassal, M Hayat, J Gouveia, D Machover, D Belpomme, L Schwarzenberg, P Ribaud, J L Pico, M Musset, C Jasmin, L de Luca
  • PMID: 273888

[Leukaemias and lymphomas treatment by vindesine. Result of a phase II trial in terms of remission induction (author's transl)]

[Article in French]
G Marthé et al. Nouv Presse Med. .

Abstract

Vindesine is a derivative of vinblastine and of vincristine. A high proportion of remissions were obtained in acute lymphoid leukaemia (6 complete and 1 incomplete remissions in 15 patients), in blastic crisis of chronic myeloid leukaemia, and a few responses have been registered in lymphosarcoma and Hodgkin's disease. Permanent 48 h i.v. infusion may include a remission where i.v. pusch of the same dose has failed. The most remarkable characteristic of vindesine is the absence of cross-resistance with vincristine as documented in acute lymphoid leukaemia.

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