doi: 10.1073/pnas.75.4.1637.
Unique structures formed by pyrimidine-purine DNAs which may be four-stranded
- PMID: 273896
- PMCID: PMC392393
- DOI: 10.1073/pnas.75.4.1637
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Unique structures formed by pyrimidine-purine DNAs which may be four-stranded
Proc Natl Acad Sci U S A.
1978 Apr.
Abstract
Pyrimidine-purine DNAs with repeating sequences can be made to undergo a reversible transition to possibly a tetra-stranded complex. Physicochemical characterization of the new structures and model building are consistent with, in the case of d(TC)n-d(GA)n, a tetra-stranded complex forming by the addition of d(GA)n to the remaining space in the major groove of the triple-stranded complex d(TC)n-d(GA)n-d(CT)n. A possible role for tetra-stranded complexes in chromosome condensation is suggested by the natural occurrence of repeating sequence pyrimidine-purine DNAs and the properties of condensed chromosomes.
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