Does Elevated Glucose Promote Atherosclerosis? Pros and Cons

Affiliations

¹ From the Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and Department of Pathology, UW Diabetes Institute, University of Washington School of Medicine, Seattle. bornf@u.washington.edu.

Review

Karin E Bornfeldt. Circ Res. 2016.

. 2016 Jul 8;119(2):190-3.

doi: 10.1161/CIRCRESAHA.116.308873.

¹ From the Department of Medicine, Division of Metabolism, Endocrinology and Nutrition and Department of Pathology, UW Diabetes Institute, University of Washington School of Medicine, Seattle. bornf@u.washington.edu.

No abstract available

Keywords: atherosclerosis; diabetes mellitus; glucose; inflammation; macrophages.

References

1. Bornfeldt KE. Uncomplicating the macrovascular complications of diabetes: The 2014 edwin bierman award lecture. Diabetes. 2015;64:2689–2697. - PMC - PubMed
1. Sarrazy V, Viaud M, Westerterp M, Ivanov S, Giorgetti-Peraldi S, Guinamard R, Gautier EL, Thorp EB, De Vivo DC, Yvan-Charvet L. Disruption of glut1 in hematopoietic stem cells prevents myelopoiesis and enhanced glucose flux in atheromatous plaques of apoe−/− mice. Circ Res. 2016 - PMC - PubMed
1. Nishizawa T, Kanter JE, Kramer F, et al. Testing the role of myeloid cell glucose flux in inflammation and atherosclerosis. Cell Rep. 2014;7:356–365. - PMC - PubMed
1. Sanman LE, Qian Y, Eisele NA, Ng TM, van der Linden WA, Monack DM, Weerapana E, Bogyo M. Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death. Elife. 2016;5 - PMC - PubMed
1. Diabetes C, Complications Trial -Epidemiology of Diabetes I, Complications Research G. Nathan DM, Bebu I, Braffett BH, Orchard TJ, Cowie CC, Lopes-Virella M, Schutta M, Lachin JM. Risk factors for cardiovascular disease in type 1 diabetes. Diabetes. 2016