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. 2015 Jul-Dec;6(2):176-9.
doi: 10.4103/0975-5950.183869.

Fucose: A biomarker in grading of oral cancer

Satish Kumar  1 , Mona Saxena  2 , Kandakurtis Srinivas  1 , Vinod Kumar Singh  2
Affiliations

Fucose: A biomarker in grading of oral cancer

Satish Kumar et al. Natl J Maxillofac Surg. 2015 Jul-Dec.

Abstract

Introduction: Early diagnosis of cancer helps a great deal in the management of oral cancer patients. Number of proteinous markers have been employed for this purpose. Majority of them are not specific. Recently conjugated oligosaccharide with proteins and lipids have gained considerable importance in the present postgenomics and postproteomic period in the diagnostic and prognostics of cancer cases.

Materials and methods: In this study, serum fucose levels were estimated in 50 control cases and 75 cases of oral cancer by the method of Dische and Shettles as adopted by Winzler.

Results: Serum fucose levels were found to be significantly higher in oral cancer cases (46.63 ± 5.29 mg/dl) as compared to the control cases (7.22 ± 0.26 mg/dl). The stepwise elevated serum fucose levels were found to be correlated with the histopathological grading of oral cancer.

Conclusions: Estimation of such fucose conjugated proteins is suggestive to be good biomarkers in the diagnosis of oral cancer cases as well as in assessing the prognosis of such cases.

Keywords: Fucosylation; oral cancer patients; prognosis; serum 6-deoxy-L-galactose.

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References

    1. Stewart BW, Kleihues P, editors. Lyon: WHO, International Agency for Research on Cancer; 2003. World Cancer Report.
    1. Rao VR, Krishnamoorthy L, Kumaraswamy SV, Ramaswamy G. Circulating levels in serum of total sialic acid, lipid-associated sialic acid, and fucose in precancerous lesion and cancer of the oral cavity. Cancer Detect Prev. 1998;22:237–40. - PubMed
    1. Reibel J. Tobacco and oral diseases. Update on the evidence, with recommendations. Med Princ Pract. 2003;12(Suppl 1):22–32. - PubMed
    1. Gokul S. Salivary diagnostics in oral cancer. In: Ogbureke KUE, editor. Oral Cancer. China: InTech; 2012. pp. 227–48.
    1. Sidransky D. Emerging molecular markers of cancer. Nat Rev Cancer. 2002;2:210–9. - PubMed