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. 2016 Jul 8;16(1):149.
doi: 10.1186/s12872-016-0320-5.

Adipo/cytokines in atherosclerotic secretomes: increased visfatin levels in unstable carotid plaque

Teresa Auguet  1   2 , Gemma Aragonès  1 , Esther Guiu-Jurado  1 , Alba Berlanga  1 , Marta Curriu  1 , Salomé Martinez  3 , Ajla Alibalic  2 , Carmen Aguilar  1 , María-Luisa Camara  4 , Esteban Hernández  5 , Xavier Ruyra  4 , Vicente Martín-Paredero  5 , Cristóbal Richart  6   7
Affiliations

Adipo/cytokines in atherosclerotic secretomes: increased visfatin levels in unstable carotid plaque

Teresa Auguet et al. BMC Cardiovasc Disord. .

Abstract

Background: Novel pro-inflammatory and anti-inflammatory derivatives from adipose tissue, known as adipokines, act as metabolic factors. The aim of this study was to analyse the secreted expression of different adipo/cytokines in secretomes of unstable carotid atherosclerotic plaque versus non-atherosclerotic mammary artery.

Methods: We evaluated the secretion levels of adiponectin, visfatin, lipocalin-2, resistin, IL-6 and TNFR2 by ELISA in human secretomes from cultured unstable carotid atherosclerotic plaque (n = 18) and non-atherosclerotic mammary artery (n = 13). We also measured visfatin serum levels in patients suffering from atherosclerosis and in a serum cohort of healthy subjects (n = 16).

Results: We found that visfatin levels were significantly increased in unstable carotid atherosclerotic plaque secretome than in non-atherosclerotic mammary artery secretome. No differences were found with regard the other adipo/cytokines studied. Regarding visfatin circulating levels, there were no differences between unstable carotid atherosclerotic plaque and non-atherosclerotic mammary artery group. However, these visfatin levels were increased in comparison to serum cohort of healthy subjects.

Conclusions: Of all the adipo/cytokines analysed, only visfatin showed increased levels in secretomes of unstable carotid atherosclerotic plaque. Additional human studies are needed to clarify the possible role of visfatin as prognostic factor of unstable carotid atherosclerotic plaque.

Keywords: Adipo/cytokines; Atheroma plaque; Atherosclerosis; Secretome; Visfatin.

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Figures

Fig. 1
Fig. 1
Visfatin serum levels in different groups: unstable carotid atherosclerotic plaque group (n = 18), coronary patients with non-atherosclerotic mammary artery (n = 13) and serum cohort of healthy subjects (n = 16). p <0.05 were considered statistically significant
See this image and copyright information in PMC

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