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. 2016 Nov;30(11):1415-1423.
doi: 10.1038/eye.2016.133. Epub 2016 Jul 8.

Spectral-domain optical coherence tomography findings of the macula in 500 consecutive patients with uveitis

R S Grajewski  1 , A C Boelke  1 , W Adler  2 , S Meyer  1 , A Caramoy  1 , B Kirchhof  1 , C Cursiefen  1 , L M Heindl  1
Affiliations

Spectral-domain optical coherence tomography findings of the macula in 500 consecutive patients with uveitis

R S Grajewski et al. Eye (Lond). 2016 Nov.

Abstract

PurposeTo analyze the macular structure in a large series of consecutive patients with different types of uveitis using spectral-domain optical coherence tomography (SD-OCT).Patients and methodsFive hundred eyes of 500 consecutive patients with anterior, intermediate, posterior, and panuveitis underwent standardized macular examination using SD-OCT. Central retinal thickness (CRT), macular volume (MV), and presence of cystoid macular edema (CME), diffuse macular edema (DME), serous retinal detachment (SRD), epiretinal membrane with (ERM+) and without (ERM-) retinal surface wrinkling were determined.ResultsThe anatomic location of inflammation affected significantly CRT and MV (P<0.001, respectively), with the highest values in intermediate and panuveitis. CME was seen in 25% of all uveitic eyes, DME in 11%, SRD in 8%, ERM+ in 18%, and ERM- in 13%. CME was most frequent in intermediate (40%) and panuveitis (36%); DME was most frequent in panuveitis (18%) and posterior uveitis (17%); SRD was most frequent in panuveitis (15%) and posterior uveitis (10%); ERM+ was most frequent in panuveitis (45%) and intermediate uveitis (30%); and ERM- was most frequent in intermediate (14%) and posterior uveitis (15%).ConclusionSD-OCT of the macula is recommended for all uveitis patients. CRT, MV, and the incidence of CME were highest in intermediate and panuveitis.

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References

    1. Foster CS, Vitale AT. Diagnosis and Treatment of Uveitis. JP Medical Ltd: New Delhi, India, 2013.
    1. de Boer J, Steijaert A, van den Bor R, Stellato R, Ossewaarde-van Norel J. Development of macular edema and impact on visual acuity in uveitis associated with juvenile idiopathic arthritis. Ocul Immunol Inflamm 2015; 23(1): 67–73. - PubMed
    1. Levin MH, Pistilli M, Daniel E, Gangaputra SS, Nussenblatt RB, Rosenbaum JT et al. Incidence of visual improvement in uveitis cases with visual impairment caused by macular edema. Ophthalmology 2014; 121(2): 588–595 e581. - PMC - PubMed
    1. Hunter RS, Skondra D, Papaliodis G, Sobrin L. Role of OCT in the diagnosis and management of macular edema from uveitis. Semin Ophthalmol 2012; 27(5-6): 236–241. - PubMed
    1. Simmons-Rear A, Yeh S, Chan-Kai BT, Lauer AK, Flaxel CJ, Smith JR et al. Characterization of serous retinal detachments in uveitis patients with optical coherence tomography. J Ophthalmic Inflamm Infect 2012; 2(4): 191–197. - PMC - PubMed