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Comment
. 2016 Jul 7;19(1):1-2.
doi: 10.1016/j.stem.2016.06.014.

Burning Fat Fuels Leukemic Stem Cell Heterogeneity

Daniel Thomas  1 , Ravindra Majeti  2
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Burning Fat Fuels Leukemic Stem Cell Heterogeneity

Daniel Thomas et al. Cell Stem Cell. .
Free article

Abstract

Obese leukemia patients exhibit reduced survival after chemotherapy, suggesting an important role of adipose tissue in disease progression. In this issue of Cell Stem Cell, Ye et al. (2016) reveal metabolic heterogeneity in leukemic stem cell (LSC) subpopulations and show that chemotherapy-resistant CD36+ LSCs co-opt gonadal adipose tissue to support their metabolism and survival.

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