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Comment
. 2016 Jul 7;19(1):3-4.
doi: 10.1016/j.stem.2016.06.016.

Metabolic RemodeLIN of Pluripotency

Julie Mathieu  1 , Hannele Ruohola-Baker  2
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Comment

Metabolic RemodeLIN of Pluripotency

Julie Mathieu et al. Cell Stem Cell. .
Free article

Abstract

Cellular metabolism is a key regulator of cell fate, including fate in pluripotent stem cells. Now in Cell Stem Cell, Zhang et al. (2016) show that Lin28 controls the metabolic transition from naive to primed pluripotency by directly repressing oxidative metabolism genes and metabolic intermediates involved in epigenetic regulation independently of let-7.

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  • LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency.
    Zhang J, Ratanasirintrawoot S, Chandrasekaran S, Wu Z, Ficarro SB, Yu C, Ross CA, Cacchiarelli D, Xia Q, Seligson M, Shinoda G, Xie W, Cahan P, Wang L, Ng SC, Tintara S, Trapnell C, Onder T, Loh YH, Mikkelsen T, Sliz P, Teitell MA, Asara JM, Marto JA, Li H, Collins JJ, Daley GQ. Zhang J, et al. Cell Stem Cell. 2016 Jul 7;19(1):66-80. doi: 10.1016/j.stem.2016.05.009. Epub 2016 Jun 16. Cell Stem Cell. 2016. PMID: 27320042

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