Modeling Zika Virus Infection in Mice

Shannan L Rossi¹, Nikos Vasilakis²

Affiliations

¹ Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0609, USA. Electronic address: slrossi@utmb.edu.
² Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, USA; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0609, USA. Electronic address: nivasila@utmb.edu.

PMID: 27392219
DOI: 10.1016/j.stem.2016.06.009

Free article

Comment

Modeling Zika Virus Infection in Mice

Shannan L Rossi et al. Cell Stem Cell. 2016.

Free article

. 2016 Jul 7;19(1):4-6.

doi: 10.1016/j.stem.2016.06.009.

Authors

Shannan L Rossi¹, Nikos Vasilakis²

Affiliations

¹ Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0609, USA. Electronic address: slrossi@utmb.edu.
² Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, USA; Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0609, USA. Electronic address: nivasila@utmb.edu.

PMID: 27392219
DOI: 10.1016/j.stem.2016.06.009

Abstract

Understanding the link between Zika virus (ZIKV) infection and microcephaly requires in vivo models of ZIKV infection in pregnant adults and fetuses. Three studies recently generated such mouse models of ZIKV infection, which corroborate previous in vitro evidence linking ZIKV infection and apoptosis induction in neurons and progenitors to microcephaly.

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Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.
Li C, Xu D, Ye Q, Hong S, Jiang Y, Liu X, Zhang N, Shi L, Qin CF, Xu Z. Li C, et al. Cell Stem Cell. 2016 Jul 7;19(1):120-6. doi: 10.1016/j.stem.2016.04.017. Epub 2016 May 11. Cell Stem Cell. 2016. PMID: 27179424
Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise.
Miner JJ, Cao B, Govero J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK, Mysorekar IU, Diamond MS. Miner JJ, et al. Cell. 2016 May 19;165(5):1081-1091. doi: 10.1016/j.cell.2016.05.008. Epub 2016 May 11. Cell. 2016. PMID: 27180225 Free PMC article.
The Brazilian Zika virus strain causes birth defects in experimental models.
Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JL, Guimarães KP, Benazzato C, Almeida N, Pignatari GC, Romero S, Polonio CM, Cunha I, Freitas CL, Brandão WN, Rossato C, Andrade DG, Faria Dde P, Garcez AT, Buchpigel CA, Braconi CT, Mendes E, Sall AA, Zanotto PM, Peron JP, Muotri AR, Beltrão-Braga PC. Cugola FR, et al. Nature. 2016 Jun 9;534(7606):267-71. doi: 10.1038/nature18296. Epub 2016 May 11. Nature. 2016. PMID: 27279226 Free PMC article.

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Modeling Zika Virus Infection in Mice

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Modeling Zika Virus Infection in Mice

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