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. 2016 Jul 7;19(1):6-8.
doi: 10.1016/j.stem.2016.06.005.

Eliminating Cancer Stem Cells in CML with Combination Transcriptional Therapy

Luis A Carvajal  1 , Ulrich Steidl  2
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Eliminating Cancer Stem Cells in CML with Combination Transcriptional Therapy

Luis A Carvajal et al. Cell Stem Cell. .
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Abstract

Leukemia stem cells (LSCs) are resistant to current therapies used to treat chronic myeloid leukemia (CML). Abraham et al. (2016) have identified a molecular network critical for CML LSC survival and propose that simultaneously targeting two of their major transcriptional regulators, p53 and c-Myc, may facilitate their eradication.

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