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. 2011 Jan-Feb;66(1):45-50.
doi: 10.2515/therapie/2011003.

Niveau de preuve du suivi thérapeutique pharmacologique de la teicoplanine

[Article in French]
Audrey Boulamery  1 , Nicolas Venisse  2 , Chantal Le Guellec  3 ; pour le groupe Suivi Thérapeutique Pharmacologique de la Société Française de Pharmacologie et de Thérapeutique
Affiliations

Niveau de preuve du suivi thérapeutique pharmacologique de la teicoplanine

[Article in French]
Audrey Boulamery et al. Therapie. 2011 Jan-Feb.

Abstract

Teicoplanin is a glycopeptid antibiotic used for treatment of serious infections caused by Gram+ bacteriae. The treatment scheme corresponds to an initial loading dose followed by maintenance dose. High interindividual pharmacokinetic variability and strong relation between high through concentrations, dose and clinical success, support the need of therapeutic drug monitoring using through concentrations. Achieving through concentrations ≥10-15 mg/L or ≥20-40 mg/L, regarding the measurement method and the infection severity, is recommended to increase clinical success rate. The level of proof of therapeutic drug monitoring is evaluated: "necessary".

Keywords: suivi thérapeutique pharmacologique; teicoplatin; teicoplatine; therapeutic drug monitoring.

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