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Review
. 2016 Jul;16(8):52.
doi: 10.1007/s11882-016-0631-8.

Airway Microbiota and the Implications of Dysbiosis in Asthma

Juliana Durack  1 , Homer A Boushey  2 , Susan V Lynch  3
Affiliations
Review

Airway Microbiota and the Implications of Dysbiosis in Asthma

Juliana Durack et al. Curr Allergy Asthma Rep. 2016 Jul.

Abstract

The mucosal surfaces of the human body are typically colonized by polymicrobial communities seeded in infancy and are continuously shaped by environmental exposures. These communities interact with the mucosal immune system to maintain homeostasis in health, but perturbations in their composition and function are associated with lower airway diseases, including asthma, a developmental and heterogeneous chronic disease with various degrees and types of airway inflammation. This review will summarize recent studies examining airway microbiota dysbioses associated with asthma and their relationship with the pathophysiology of this disease.

Keywords: Airway microbiome; Asthma; Asthma risk; Environment and asthma; Microbial dysbiosis.

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References

    1. Am J Respir Crit Care Med. 2009 Sep 1;180(5):388-95 - PubMed
    1. J Allergy Clin Immunol. 2010 Aug;126(2):410-2, 412.e1-3 - PubMed
    1. J Allergy Clin Immunol. 2013 Jan;131(1):23-30 - PubMed
    1. Cell. 2014 Nov 6;159(4):789-99 - PubMed
    1. Pediatr Infect Dis J. 2015 Oct;34(10):1056-62 - PubMed

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