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. 2016 Sep;5(9):455-65.
doi: 10.1002/psp4.12102. Epub 2016 Aug 29.

A Tutorial on Pharmacodynamic Scripting Facility in Simcyp

K Abduljalil  1 , D Edwards  2 , A Barnett  2 , R H Rose  2 , T Cain  2 , M Jamei  2
Affiliations

A Tutorial on Pharmacodynamic Scripting Facility in Simcyp

K Abduljalil et al. CPT Pharmacometrics Syst Pharmacol. 2016 Sep.
No abstract available

Keywords: Covariates; Lua; PBPK; Pharmacometrics; Physiologically based Pharmacokinetics Pharmacodynamics; Population Modelling and Simulation.

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Figures

Figure 1
Figure 1
Simcyp PD response unit structure and interconnections enabling various combinations of PD units up to three layers.
Figure 2
Figure 2
General scheme shows the Custom PD Step within the PD Units Chain. The figure shows how the Custom Step replaces a default PD Step. Each figure block can be equivalent to a single script containing one or more functions. The output function, Rxu1, from an upstream step “1” is considered as an input function to the PD Custom Step, Xu,custom, while the output from the custom step, Rxu,custom, is considered as an input function, Xu3, to a subsequent step “3”.
Figure 3
Figure 3
A screenshot of the Simcyp Lua Editor shows the Functions dropdown menu. The expanded menu shows how to access various get functions templates to get individual covariates.
Figure 4
Figure 4
Simcyp datastores for persistence of script variables at the different scoping levels, together with the Setup, Step, and Simcyp library (sc:) functions and Lua code that can access or modify them. Higher level stores can provide default parameters for lower level access when a requested value is not available at the same level as the get call. The set functions typically set store values at the same level as the function call. sc:sampleIIVDistribution generates individual values from the parameter distribution stored at the next higher level.
Figure 5
Figure 5
Simcyp Lua code for INR model after warfarin administration (based on Ref. 12).
See this image and copyright information in PMC

References

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