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Comment
. 2016 Aug;26(8):562-563.
doi: 10.1016/j.tcb.2016.06.007. Epub 2016 Jul 6.

The Taming of the TAMs

Joan Seoane  1
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The Taming of the TAMs

Joan Seoane. Trends Cell Biol. 2016 Aug.

Abstract

Tumor-associated macrophages and microglia (TAMs) are considered crucial elements in cancer progression. Recent work reveals the molecular mechanisms underlying acquired resistance to colony-stimulating factor-1 receptor (CSF-1R) inhibitors in glioblastoma (GBM) and shows that targeting TAMs with CSF-1R inhibitors leads to an antitumor response in GBM followed by the acquisition of resistance to treatment through the induction of insulin-like growth factor 1 (IGF-1) expression in TAMs.

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