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. 2016 Aug 15:297:38-45.
doi: 10.1016/j.jneuroim.2016.05.004. Epub 2016 May 10.

Impaired regulatory B cells in myasthenia gravis

Jian Rong Sheng  1 , Kourosh Rezania  1 , Betty Soliven  2
Affiliations

Impaired regulatory B cells in myasthenia gravis

Jian Rong Sheng et al. J Neuroimmunol. .

Abstract

Regulatory B cells (Bregs) attenuate the severity of experimental autoimmune myasthenia gravis (EAMG) in an interleukin-10 (IL-10)-dependent manner. The goal of this study was to investigate the role of human Bregs in MG focusing on CD19(+)CD1d(hi) CD5(+) and CD19(+)CD24(hi)CD38(hi) subsets. We found that MG patients exhibited a decrease in the frequency of both Breg subsets and IL-10 producing B cells within each subset, which correlated with disease severity. In addition, there was impaired suppression of Th1 polarization in MG. These findings, taken together with EAMG data, indicate that Bregs play an important role in regulating the severity of MG.

Keywords: B cells; Bregs; Cytokines; IL-10; Immune regulation; Neuromuscular junction disorders.

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