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. 1989 Jul 13;340(6229):122-6.
doi: 10.1038/340122a0.

Mapping the transition state and pathway of protein folding by protein engineering

A Matouschek  1 , J T Kellis Jr, L Serrano, A R Fersht
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Mapping the transition state and pathway of protein folding by protein engineering

A Matouschek et al. Nature. .

Abstract

In the transition state for unfolding of barnase, the hydrophobic core between the major alpha-helix and beta-sheet is somewhat weakened, the C terminus of the major helix is largely intact but its N terminus is exposed and a major loop has been invaded by solvent.

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  • Folding pathway enigma.
    Buchner J, Kiefhaber T. Buchner J, et al. Nature. 1990 Feb 15;343(6259):601-2. doi: 10.1038/343601b0. Nature. 1990. PMID: 2304534 No abstract available.

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