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Review
. 2016 Mar 14:44:1.
doi: 10.1186/s41182-016-0004-y. eCollection 2016.

Human antibody response to dengue virus: implications for dengue vaccine design

Meng Ling Moi  1 , Tomohiko Takasaki  2 , Ichiro Kurane  2
Affiliations
Review

Human antibody response to dengue virus: implications for dengue vaccine design

Meng Ling Moi et al. Trop Med Health. .

Abstract

Dengue, a global health threat, is a leading cause of morbidity and mortality in most tropical and subtropical countries. Dengue can range from asymptomatic, relatively mild dengue fever to severe and life-threatening dengue hemorrhagic fever. Disease severity and outcome is largely associated with the host immune response. Several candidate vaccines in clinical trials appear promising as effective measures for dengue disease control. Vaccine development has been hampered by safety and efficacy issues, driven by a lack of understanding of the host immune response. This review focuses on recent research findings on the dengue host immune response, particularly in humans, and the relevance of these findings to challenges in vaccine development.

Keywords: Antibody-dependent enhancement; Dengue virus; Disease protection; FcgammaR-expressing cells; Vaccine.

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References

    1. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, Myers MF, George DB, Jaenisch T, Wint GR, Simmons CP, Scott TW, Farrar JJ, Hay SI. The global distribution and burden of dengue. Nature. 2013;496(7446):504–507. doi: 10.1038/nature12060. - DOI - PMC - PubMed
    1. World Health Organization. Dengue and severe dengue haemorrhagic fever. Available at: http://www.who.int/mediacentre/factsheets/fs117/en/. Accessed 23 February 2016.
    1. Marchand E, Prat C, Jeannin C, Lafont E, Bergmann T, Flusin O, Rizzi J, Roux N, Busso V, Deniau J, Noel H, Vaillant V, Leparc-Goffart I, Six C, Paty MC. Autochthonous case of dengue in France, October 2013. Euro Surveill. 2013;18(50):20661. doi: 10.2807/1560-7917.ES2013.18.50.20661. - DOI - PubMed
    1. Lin CC, Huang YH, Shu PY, Wu HS, Lin YS, Yeh TM, Liu HS, Liu CC, Lei HY. Characteristic of dengue disease in Taiwan: 2002–2007. Am J Trop Med Hyg. 2010;82(4):731–739. doi: 10.4269/ajtmh.2010.09-0549. - DOI - PMC - PubMed
    1. Gjenero-Margan I, Aleraj B, Krajcar D, Lesnikar V, Klobučar A, Pem-Novosel I, Kurečić-Filipović S, Komparak S, Martić R, Duričić S, Betica-Radić L, Okmadžić J, Vilibić-Čavlek T, Babić-Erceg A, Turković B, Avsić-Županc T, Radić I, Ljubić M, Sarac K, Benić N, Mlinarić-Galinović G. Autochthonous dengue fever in Croatia, August-September 2010. Euro Surveill. 2011;16:9. - PubMed

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