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Review
. 2016 Jun 15;8(6):2490-7.
eCollection 2016.

Inflammatory bowel disease related innate immunity and adaptive immunity

Yuan Huang  1 , Zhonge Chen  2
Affiliations
Review

Inflammatory bowel disease related innate immunity and adaptive immunity

Yuan Huang et al. Am J Transl Res. .

Abstract

Inflammatory bowel disease (IBD) is a chronic nonspecific intestinal inflammatory disease, including ulcerative colitis (UC) and Crohn's disease (CD). Its pathogenesis remains not yet clear. Current researchers believe that after environmental factors act on individuals with genetic susceptibility, an abnormal intestinal immune response is launched under stimulation of intestinal flora. However, previous studies only focused on adaptive immunity in the pathogenesis of IBD. Currently, roles of innate immune response in the pathogenesis of intestinal inflammation have also drawn much attention. In this study, IBD related innate immunity and adaptive immunity were explained, especially the immune mechanisms in the pathogenesis of IBD.

Keywords: Inflammatory bowel disease; adaptive immunity; innate immunity; pathogenesis.

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Figures

Figure 1
Figure 1
Inflammatory bowel disease related immune disorders. The innate immune abnormalities of inflammatory bowel disease lead to adaptive immune disorders (Th1/Th2 regulation imbalance and Th17/Treg transformation imbalance). The inflammatory cytokines in turn increase the innate immune damages (apoptosis of intestinal epithelial cells, reduction of connection protein expression, decrease of antibacterial peptides secreted by Paneth cells, etc.), abate the intestinal barrier function, and aggravate inflammation. Therefore a vicious circle forms.
See this image and copyright information in PMC

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